TY - JOUR
T1 - Endoplasmic reticulum stress inhibition enhances liver tolerance to ischemia/reperfusion
AU - Peralta, C.
AU - Brenner, C.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - In many physiopathological conditions, the cell controls its proper dysfunction via activation of the unfolded protein response to restore efficient protein synthesis and folding in the endoplasmic reticulum. However, whether the aim of unfolded protein response is to promote the cell survival, it can also lead to induction of cell death and then affect the cell fate. Recently, endoplasmic reticulum stress appeared to be critical for acute as well as chronic diseases including neurodegeneration, cardiac disease, cancer, obesity, type 2 diabetes, and ischemia/reperfusion injury. Therefore, inhibition of the endoplasmic reticulum stress could constitute a promising therapeutic strategy to limit cellular damage in pathologies such as hepatic ischemia/reperfusion.
AB - In many physiopathological conditions, the cell controls its proper dysfunction via activation of the unfolded protein response to restore efficient protein synthesis and folding in the endoplasmic reticulum. However, whether the aim of unfolded protein response is to promote the cell survival, it can also lead to induction of cell death and then affect the cell fate. Recently, endoplasmic reticulum stress appeared to be critical for acute as well as chronic diseases including neurodegeneration, cardiac disease, cancer, obesity, type 2 diabetes, and ischemia/reperfusion injury. Therefore, inhibition of the endoplasmic reticulum stress could constitute a promising therapeutic strategy to limit cellular damage in pathologies such as hepatic ischemia/reperfusion.
KW - Cell death
KW - Chemotherapy
KW - Endoplasmic reticulum
KW - Mitochondrion
KW - Unfolded protein response
UR - http://www.scopus.com/inward/record.url?scp=79957948453&partnerID=8YFLogxK
U2 - 10.2174/092986711795590039
DO - 10.2174/092986711795590039
M3 - Article
AN - SCOPUS:79957948453
SN - 0929-8673
VL - 18
SP - 2016
EP - 2024
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
IS - 13
ER -