Enhancing radioprotection: A chitosan-based chelating polymer is a versatile radioprotective agent for prophylactic and therapeutic interventions against radionuclide contamination

Arthur Durand, Tatiana Borisova, François Lux, Jordyn A. Howard, Augustin Tillement, Halyna Kuznietsova, Natalia Dziubenko, Vladimir Lysenko, Laurent David, Daphné Morel, Ross Berbeco, Serhiy Komisarenko, Olivier Tillement, Eric Deutsch

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    Résumé

    To mitigate the risk of radioactive isotope dissemination, the development of preventative and curative measures is of particular interest. For mass treatment, the developed solution must be easily administered, preferably orally, with effective, nontoxic decorporating properties against a wide range of radioactive isotopes. Currently, most orally administered chelation therapy products are quickly absorbed into the blood circulation, where chelation of the radioactive isotope is a race against time due to the short circulation half-life of the therapeutic. This report presents an alternative therapeutic approach by using a functionalized chitosan (chitosan@DOTAGA) with chelating properties that remains within the gastrointestinal tract and is eliminated in feces, that can protect against ingested radioactive isotopes. The polymer shows important in vitro chelation properties towards different metallic cations of importance, including (Cs(I), Ir(III), Th(IV), Tl(I), Sr(II), U(VI) and Co(II)), at different pH (from 1 to 7) representing the different environments in the gastrointestinal tract. An in vivo proof of concept is presented on a rodent model of uranium contamination following an oral administration of Chitosan@DOTAGA. The polymer partially prevents the accumulation of uranium within the kidneys (providing a protective effect) and completely prevents its uptake by the spleen.

    langue originaleAnglais
    Numéro d'articlee0292414
    journalPLoS ONE
    Volume19
    Numéro de publication4 April
    Les DOIs
    étatPublié - 1 avr. 2024

    Contient cette citation