Establishing the Evidence Bar for Molecular Diagnostics in Personalised Cancer Care

Daniel Schneider, Giampaolo Bianchini, Denis Horgan, Stefan Michiels, Wim Witjes, Robert Hills, Juliette Plun-Favreau, Angela Brand, Mark Lawler

Résultats de recherche: Contribution à un journalArticleRevue par des pairs

10 Citations (Scopus)

Résumé

While personalised cancer medicine holds great promise, targeting therapies to the biological characteristics of patients is limited by the number of validated biomarkers currently available. The implementation of biomarkers has undergone many challenges with few biomarkers reaching cancer patients in the clinic. There have been many biomarkers that have been published and claimed to be therapeutically useful, but few become part of the clinical decision-making process due to technical, validation and market access issues. To reduce this attrition rate, there is a significant need for policy makers and reimbursement agencies to define specific evidence requirements for the introduction of biomarkers into clinical practice. Once these requirements are more clearly defined, in an analogous manner to pharmaceuticals, researchers and diagnostic companies can better focus their biomarker research and development on meeting these specific requirements, which should lead to the more rapid introduction of new molecular oncology tests for patient benefit.

langue originaleAnglais
Pages (de - à)349-358
Nombre de pages10
journalPublic Health Genomics
Volume18
Numéro de publication6
Les DOIs
étatPublié - 1 déc. 2015
Modification externeOui

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