Ethiodized oil as an imaging biomarker after conventional transarterial chemoembolization

Mishal Mendiratta-Lala, Anum Aslam, Harrison X. Bai, Julius Chapiro, Thiery De Baere, Shiro Miyayama, Victoria Chernyak, Osamu Matsui, Valerie Vilgrain, Nicholas Fidelman

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    3 Citations (Scopus)

    Résumé

    Abstract: Conventional transarterial chemoembolization (cTACE) utilizing ethiodized oil as a chemotherapy carrier has become a standard treatment for intermediate-stage hepatocellular carcinoma (HCC) and has been adopted as a bridging and downstaging therapy for liver transplantation. Water-in-oil emulsion made up of ethiodized oil and chemotherapy solution is retained in tumor vasculature resulting in high tissue drug concentration and low systemic chemotherapy doses. The density and distribution pattern of ethiodized oil within the tumor on post-treatment imaging are predictive of the extent of tumor necrosis and duration of response to treatment. This review describes the multiple roles of ethiodized oil, particularly in its role as a biomarker of tumor response to cTACE. Clinical relevance: With the increasing complexity of locoregional therapy options, including the use of combination therapies, treatment response assessment has become challenging; Ethiodized oil deposition patterns can serve as an imaging biomarker for the prediction of treatment response, and perhaps predict post-treatment prognosis. Key Points: • Treatment response assessment after locoregional therapy to hepatocellular carcinoma is fraught with multiple challenges given the varied post-treatment imaging appearance. • Ethiodized oil is unique in that its’ radiopacity can serve as an imaging biomarker to help predict treatment response. • The pattern of deposition of ethiodozed oil has served as a mechanism to detect portions of tumor that are undertreated and can serve as an adjunct to enhancement in order to improve management in patients treated with intraarterial embolization with ethiodized oil.

    langue originaleAnglais
    Pages (de - à)3284-3297
    Nombre de pages14
    journalEuropean Radiology
    Volume34
    Numéro de publication5
    Les DOIs
    étatPublié - 1 mai 2024

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