@article{eef9f5066dea4154892b85e405cc0bf9,
title = "ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia",
abstract = "Chimeric transcription factors are a hallmark of human leukemia, but the molecular mechanisms by which they block differentiation and promote aberrant self-renewal remain unclear. Here, we demonstrate that the ETO2-GLIS2 fusion oncoprotein, which is found in aggressive acute megakaryoblastic leukemia, confers megakaryocytic identity via the GLIS2 moiety while both ETO2 and GLIS2 domains are required to drive increased self-renewal properties. ETO2-GLIS2 directly binds DNA to control transcription of associated genes by upregulation of expression and interaction with the ETS-related ERG protein at enhancer elements. Importantly, specific interference with ETO2-GLIS2 oligomerization reverses the transcriptional activation at enhancers and promotes megakaryocytic differentiation, providing a relevant interface to target in this poor-prognosis pediatric leukemia.",
keywords = "AMKL, CBFA2T3, CRISPR, ChIP, ERG, GLIS, enhancer, leukemia, pediatric, transcription factor",
author = "C{\'e}cile Thirant and Cathy Ignacimouttou and Lopez, {C{\'e}cile K.} and M'Boyba Diop and {Le Mou{\"e}l}, Lou and Clarisse Thiollier and Aur{\'e}lie Siret and Phillipe Dessen and Zakia Aid and Julie Rivi{\`e}re and Philippe Rameau and C{\'e}line Lefebvre and Mehdi Khaled and Guy Leverger and Paola Ballerini and Arnaud Petit and Hana Raslova and Carmichael, {Catherine L.} and Kile, {Benjamin T.} and Eric Soler and Crispino, {John D.} and Christian Wichmann and Fran{\c c}oise Pflumio and J{\"u}rg Schwaller and William Vainchenker and Camille Lobry and Nathalie Droin and Bernard, {Olivier A.} and S{\'e}bastien Malinge and Thomas Mercher",
note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",
year = "2017",
month = mar,
day = "13",
doi = "10.1016/j.ccell.2017.02.006",
language = "English",
volume = "31",
pages = "452--465",
journal = "Cancer Cell",
issn = "1535-6108",
number = "3",
}