ETS Fight Club on Microsatellite Enhancers

Thomas Mercher

doi:10.1158/2643-3230.BCD-22-0177

ETS Fight Club on Microsatellite Enhancers

Thomas Mercher

Résultats de recherche: Contribution à un journal › Article 'review' › Revue par des pairs

Résumé

In this issue of Blood Cancer Discovery, Kodgule, Goldman, Monovich et al. cleverly analyzed the transcription regulatory elements to investigate why the second copy of ETV6 is often lost in ETV6::RUNX1translocated in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). It turns out that ETV6 suppresses the enhancer activity of GGAA microsatellite repeats, preventing ERG from subverting them to activate aberrant oncogene transcription.

langue originale	Anglais
Pages (de - à)	2-4
Nombre de pages	3
journal	Blood Cancer Discovery
Volume	4
Numéro de publication	1
Les DOIs	https://doi.org/10.1158/2643-3230.BCD-22-0177
état	Publié - 1 janv. 2023
Modification externe	Oui

Accès au document

10.1158/2643-3230.BCD-22-0177

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Contient cette citation

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title = "ETS Fight Club on Microsatellite Enhancers",

abstract = "In this issue of Blood Cancer Discovery, Kodgule, Goldman, Monovich et al. cleverly analyzed the transcription regulatory elements to investigate why the second copy of ETV6 is often lost in ETV6::RUNX1translocated in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). It turns out that ETV6 suppresses the enhancer activity of GGAA microsatellite repeats, preventing ERG from subverting them to activate aberrant oncogene transcription.",

author = "Thomas Mercher",

note = "Publisher Copyright: {\textcopyright}2022 American Association for Cancer Research.",

year = "2023",

month = jan,

day = "1",

doi = "10.1158/2643-3230.BCD-22-0177",

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AB - In this issue of Blood Cancer Discovery, Kodgule, Goldman, Monovich et al. cleverly analyzed the transcription regulatory elements to investigate why the second copy of ETV6 is often lost in ETV6::RUNX1translocated in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). It turns out that ETV6 suppresses the enhancer activity of GGAA microsatellite repeats, preventing ERG from subverting them to activate aberrant oncogene transcription.

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U2 - 10.1158/2643-3230.BCD-22-0177

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M3 - Review article

AN - SCOPUS:85160851467

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VL - 4

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JO - Blood Cancer Discovery

JF - Blood Cancer Discovery

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ER -