TY - JOUR
T1 - Exogenous reproductive hormone use in breast cancer survivors and previvors
AU - Vaz-Luis, Ines
AU - Partridge, Ann H.
N1 - Publisher Copyright:
© 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Considerable controversy exists regarding the safety of elective exogenous hormonal exposure among breast cancer survivors and women at high risk of developing the disease (referred to herein as 'previvors'). We performed a qualitative analysis focused on four areas of potential exogenous exposure to hormones among previvors and survivors: hormonal contraception; systemic hormone-replacement therapy (HRT); localized HRT; and hormonal manipulation for fertility preservation or enhancement. Herein, we discuss the available data and present clinical recommendations regarding the safety of hormonal exposure for both previvors and survivors. We found these data to be hampered by small cohort sizes, heterogeneous patient populations, and limited study designs, highlighting a great need to conduct further research with the aim of enabling better-informed patient management.
AB - Considerable controversy exists regarding the safety of elective exogenous hormonal exposure among breast cancer survivors and women at high risk of developing the disease (referred to herein as 'previvors'). We performed a qualitative analysis focused on four areas of potential exogenous exposure to hormones among previvors and survivors: hormonal contraception; systemic hormone-replacement therapy (HRT); localized HRT; and hormonal manipulation for fertility preservation or enhancement. Herein, we discuss the available data and present clinical recommendations regarding the safety of hormonal exposure for both previvors and survivors. We found these data to be hampered by small cohort sizes, heterogeneous patient populations, and limited study designs, highlighting a great need to conduct further research with the aim of enabling better-informed patient management.
UR - http://www.scopus.com/inward/record.url?scp=85044198011&partnerID=8YFLogxK
U2 - 10.1038/nrclinonc.2017.207
DO - 10.1038/nrclinonc.2017.207
M3 - Review article
C2 - 29358778
AN - SCOPUS:85044198011
SN - 1759-4774
VL - 15
SP - 249
EP - 261
JO - Nature Reviews Clinical Oncology
JF - Nature Reviews Clinical Oncology
IS - 4
ER -