Expression and proliferative effect of hemokinin-1 in human B-cells

Stanislas Grassin-Delyle, Amparo Buenestado, Laurent Vallat, Emmanuel Naline, Sirima Marx, Julie Decocq, Patrice Debré, Olivier A. Bernard, Charles Advenier, Philippe Devillier, Hélne Merle-Béral

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    14 Citations (Scopus)

    Résumé

    Tachykinins are a family of structurally related peptides, including substance P (SP), hemokinin-1 (HK-1), neurokinin A (NKA), and neurokinin B. SP and NKA have been shown to modulate hematopoiesis and rat/mouse HK-1 has been found to be involved in the survival and differentiation of mouse B-cells. This study was designed to assess the expression of tachykinins with a focus on human HK-1 (hHK-1) in human B lymphocytes and the role of these peptides in cell differentiation, apoptosis and proliferation. Expression of tachykinin and tachykinin receptor mRNA was determined quantitatively in human B lymphoproliferative malignancies and compared to normal B-cells. Expression of hHK-1 and NK1 receptor, but not SP, was detected in human B-lymphocytes, and was up-regulated in B-lymphocytes from chronic lymphocytic leukemia and non-Hodgkin's lymphoma, while it was down-regulated in acute lymphoblastic leukemia. Moreover, hHK-1, in contrast to SP, was able to induce proliferation of human pre-B lymphocytes through a NK1 receptor-independent mechanism. These data suggest a role for hHK-1 in normal and pathological B lymphopoiesis, and open the door to a better understanding of the physiopathological mechanisms leading to lymphoproliferative malignancies.

    langue originaleAnglais
    Pages (de - à)1027-1034
    Nombre de pages8
    journalPeptides
    Volume32
    Numéro de publication5
    Les DOIs
    étatPublié - 1 mai 2011

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