TY - JOUR
T1 - Expression of multidrug-resistance (MDR1) gene in normal epithelia and in invasive carcinomas of the uterine cervix
AU - Riou, Guy F.
AU - Zhou, Dany
AU - Ahomadegbe, Jean Charles
AU - Gabillot, Michèle
AU - Duvillard, Pierre
AU - Lhomme, Catherine
PY - 1990/9/19
Y1 - 1990/9/19
N2 - Total RNA from 92 invasive cervical cancers was analyzed for the presence of multidrug-resistance (MDR1) gene (also known as PGY1) transcripts. A 4.5-kilobase MDR1 transcript band was detected in 40 (43%) of 92 invasive cervical carcinomas and in 15 (68%) of 22 normal cervices. MDR1 levels were low [mean, 2.5 arbitrary units (U)] except in one liver metastasis (50 U) treated with a drug regimen including vincristine. Of eight carcinomas treated by radiotherapy and/or chemotherapy, seven (88%) exhibited MDR1 transcripts as compared with 24 (35%) of 69 untreated carcinomas (Fisher's exact test; P =.01). In conclusion, our data suggest that the MDR1 gene plays a role in drug resistance of certain cervical cancers, but also that other mechanisms may be involved. [J Natl Cancer Inst 82: 1493-1496, 1990]
AB - Total RNA from 92 invasive cervical cancers was analyzed for the presence of multidrug-resistance (MDR1) gene (also known as PGY1) transcripts. A 4.5-kilobase MDR1 transcript band was detected in 40 (43%) of 92 invasive cervical carcinomas and in 15 (68%) of 22 normal cervices. MDR1 levels were low [mean, 2.5 arbitrary units (U)] except in one liver metastasis (50 U) treated with a drug regimen including vincristine. Of eight carcinomas treated by radiotherapy and/or chemotherapy, seven (88%) exhibited MDR1 transcripts as compared with 24 (35%) of 69 untreated carcinomas (Fisher's exact test; P =.01). In conclusion, our data suggest that the MDR1 gene plays a role in drug resistance of certain cervical cancers, but also that other mechanisms may be involved. [J Natl Cancer Inst 82: 1493-1496, 1990]
UR - http://www.scopus.com/inward/record.url?scp=0024989789&partnerID=8YFLogxK
U2 - 10.1093/jnci/82.18.1493
DO - 10.1093/jnci/82.18.1493
M3 - Article
C2 - 1697346
AN - SCOPUS:0024989789
SN - 0027-8874
VL - 82
SP - 1493
EP - 1496
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 18
ER -