Expression of multidrug-resistance (MDR1) gene in normal epithelia and in invasive carcinomas of the uterine cervix

Guy F. Riou, Dany Zhou, Jean Charles Ahomadegbe, Michèle Gabillot, Pierre Duvillard, Catherine Lhomme

Résultats de recherche: Contribution à un journalArticleRevue par des pairs

19 Citations (Scopus)

Résumé

Total RNA from 92 invasive cervical cancers was analyzed for the presence of multidrug-resistance (MDR1) gene (also known as PGY1) transcripts. A 4.5-kilobase MDR1 transcript band was detected in 40 (43%) of 92 invasive cervical carcinomas and in 15 (68%) of 22 normal cervices. MDR1 levels were low [mean, 2.5 arbitrary units (U)] except in one liver metastasis (50 U) treated with a drug regimen including vincristine. Of eight carcinomas treated by radiotherapy and/or chemotherapy, seven (88%) exhibited MDR1 transcripts as compared with 24 (35%) of 69 untreated carcinomas (Fisher's exact test; P =.01). In conclusion, our data suggest that the MDR1 gene plays a role in drug resistance of certain cervical cancers, but also that other mechanisms may be involved. [J Natl Cancer Inst 82: 1493-1496, 1990]

langue originaleAnglais
Pages (de - à)1493-1496
Nombre de pages4
journalJournal of the National Cancer Institute
Volume82
Numéro de publication18
Les DOIs
étatPublié - 19 sept. 1990
Modification externeOui

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