TY - JOUR
T1 - Expression of p53 protein in borderline epithelial ovarian tumors
T2 - A clinicopathologic study of 39 cases
AU - Darai, E.
AU - Walker-Combrouze, F.
AU - Mlika-Cabanne, N.
AU - Feldmann, G.
AU - Madelenat, P.
AU - Scoazec, J. Y.
PY - 1998/4/28
Y1 - 1998/4/28
N2 - Objective: To evaluate the expression of p53 protein in borderline ovarian tumors and its correlations with the clinicopathological parameters. Study design: p53 protein was detected by immunoperoxidase in 79 ovarian tumors (39 borderline, 20 malignant, 20 benign). p53 expression was compared to histological type, FIGO stage, age, presence of ascites, recurrence and patient survival. Results: The median value of quantitative p53 immunopositivity was: 0.80 ± 0.42 in ovarian cancers, 0 ± 0.24 in borderline tumors and 0 ± 0.16 in benign tumors (p = 0.001). In borderline tumors, no correlation existed between p53 expression and the histological or clinical parameters. In malignant tumors, no correlation existed between the expression of p53 and patient survival. Conclusion: We found no correlation between p53 immunopositivity and clinicopathological parameters in carcinomas and borderline tumors of the ovary. p53 immunopositivity may help in distinguishing borderline tumors from ovarian cancers.
AB - Objective: To evaluate the expression of p53 protein in borderline ovarian tumors and its correlations with the clinicopathological parameters. Study design: p53 protein was detected by immunoperoxidase in 79 ovarian tumors (39 borderline, 20 malignant, 20 benign). p53 expression was compared to histological type, FIGO stage, age, presence of ascites, recurrence and patient survival. Results: The median value of quantitative p53 immunopositivity was: 0.80 ± 0.42 in ovarian cancers, 0 ± 0.24 in borderline tumors and 0 ± 0.16 in benign tumors (p = 0.001). In borderline tumors, no correlation existed between p53 expression and the histological or clinical parameters. In malignant tumors, no correlation existed between the expression of p53 and patient survival. Conclusion: We found no correlation between p53 immunopositivity and clinicopathological parameters in carcinomas and borderline tumors of the ovary. p53 immunopositivity may help in distinguishing borderline tumors from ovarian cancers.
KW - Benign ovarian tumor
KW - Borderline ovarian tumor
KW - Immunohistochemistry
KW - Ovarian cancer
KW - p53 protein
UR - http://www.scopus.com/inward/record.url?scp=0031941032&partnerID=8YFLogxK
M3 - Article
C2 - 9611054
AN - SCOPUS:0031941032
SN - 0392-2936
VL - 19
SP - 144
EP - 149
JO - European Journal of Gynaecological Oncology
JF - European Journal of Gynaecological Oncology
IS - 2
ER -