TY - JOUR
T1 - Facteurs oncogéniques de la dissémination métastatique du neuroblastome.
AU - Da Silva, J.
AU - Duarte, N.
AU - Cappellen, D.
AU - Bettan-Renaud, L.
AU - Dubourg, C.
AU - Ferrandis, E.
AU - Guigay, J.
AU - Schrodt, S.
AU - McDowell, H.
AU - Barrois, M.
AU - Ahomadegbe, J. C.
AU - Terrier-Lacombe, M. J.
AU - Bourhis, J.
AU - Hartmann, O.
AU - Benard, J.
PY - 1998/1/1
Y1 - 1998/1/1
N2 - Disseminated neuroblastoma frequently show a very poor prognosis. N-myc gene amplification, 1p deletion and lack of CD44 gene expression, are all genetic factors associated with the disease's dissemination. Human neuroblastoma xenografts in nude mice has permitted to characterize, in disseminated neuroblasts, oncogenes overexpression, inactivation of tumor suppressor genes as well as detoxifying genes activation which contributes to increase cellular resistance to chemotherapy. These genetic abnormalities permit to propose a nosology of this very aggressive pediatric solid tumor. Hopefully, this genetic classification could be of great value for new therapeutic approaches.
AB - Disseminated neuroblastoma frequently show a very poor prognosis. N-myc gene amplification, 1p deletion and lack of CD44 gene expression, are all genetic factors associated with the disease's dissemination. Human neuroblastoma xenografts in nude mice has permitted to characterize, in disseminated neuroblasts, oncogenes overexpression, inactivation of tumor suppressor genes as well as detoxifying genes activation which contributes to increase cellular resistance to chemotherapy. These genetic abnormalities permit to propose a nosology of this very aggressive pediatric solid tumor. Hopefully, this genetic classification could be of great value for new therapeutic approaches.
UR - http://www.scopus.com/inward/record.url?scp=0031610492&partnerID=8YFLogxK
M3 - Article 'review'
C2 - 9759369
AN - SCOPUS:0031610492
SN - 0037-9026
VL - 192
SP - 261
EP - 271
JO - Comptes rendus des séances de la Société de biologie et de ses filiales
JF - Comptes rendus des séances de la Société de biologie et de ses filiales
IS - 2
ER -