Facteurs oncogéniques de la dissémination métastatique du neuroblastome.

J. Da Silva, N. Duarte, D. Cappellen, L. Bettan-Renaud, C. Dubourg, E. Ferrandis, J. Guigay, S. Schrodt, H. McDowell, M. Barrois, J. C. Ahomadegbe, M. J. Terrier-Lacombe, J. Bourhis, O. Hartmann, J. Benard

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    Résumé

    Disseminated neuroblastoma frequently show a very poor prognosis. N-myc gene amplification, 1p deletion and lack of CD44 gene expression, are all genetic factors associated with the disease's dissemination. Human neuroblastoma xenografts in nude mice has permitted to characterize, in disseminated neuroblasts, oncogenes overexpression, inactivation of tumor suppressor genes as well as detoxifying genes activation which contributes to increase cellular resistance to chemotherapy. These genetic abnormalities permit to propose a nosology of this very aggressive pediatric solid tumor. Hopefully, this genetic classification could be of great value for new therapeutic approaches.

    Titre traduit de la contributionOncogenic factors of metastatic dissemination in neuroblastoma
    langue originaleFrançais
    Pages (de - à)261-271
    Nombre de pages11
    journalComptes rendus des séances de la Société de biologie et de ses filiales
    Volume192
    Numéro de publication2
    étatPublié - 1 janv. 1998

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