Familial primary mediastinal nonseminomatous germ-cell tumors

Adina Marti; Stéphane Culine; Patrice Carde; Bertrand Paugam; Karim Fizazi

doi:10.1016/S1078-1439(03)00178-9

Familial primary mediastinal nonseminomatous germ-cell tumors

Adina Marti, Stéphane Culine, Patrice Carde, Bertrand Paugam, Karim Fizazi

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

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Résumé

In this article, we describe the case of 4 brothers, 2 of which had primary mediastinal nonseminomatous germ cell tumors (PMNSGCT), while the other 2 had benign mediastinal disease. We discuss the relationship between these diseases of the mediastinum and the thymic microenvironment. Additionally, we suggest that a genetic predisposition for germ-cell tumors (GCT) may be involved since the parents were relatives.

langue originale	Anglais
Pages (de - à)	421-424
Nombre de pages	4
journal	Urologic Oncology: Seminars and Original Investigations
Volume	22
Numéro de publication	5
Les DOIs	https://doi.org/10.1016/S1078-1439(03)00178-9
état	Publié - 1 janv. 2004

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10.1016/S1078-1439(03)00178-9

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title = "Familial primary mediastinal nonseminomatous germ-cell tumors",

abstract = "In this article, we describe the case of 4 brothers, 2 of which had primary mediastinal nonseminomatous germ cell tumors (PMNSGCT), while the other 2 had benign mediastinal disease. We discuss the relationship between these diseases of the mediastinum and the thymic microenvironment. Additionally, we suggest that a genetic predisposition for germ-cell tumors (GCT) may be involved since the parents were relatives.",

keywords = "Chemotherapy, Genetics, Primary mediastinal nonseminomatous germ cell tumor, Thymus microenvironment",

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AU - Culine, Stéphane

AU - Carde, Patrice

AU - Paugam, Bertrand

AU - Fizazi, Karim

PY - 2004/1/1

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N2 - In this article, we describe the case of 4 brothers, 2 of which had primary mediastinal nonseminomatous germ cell tumors (PMNSGCT), while the other 2 had benign mediastinal disease. We discuss the relationship between these diseases of the mediastinum and the thymic microenvironment. Additionally, we suggest that a genetic predisposition for germ-cell tumors (GCT) may be involved since the parents were relatives.

AB - In this article, we describe the case of 4 brothers, 2 of which had primary mediastinal nonseminomatous germ cell tumors (PMNSGCT), while the other 2 had benign mediastinal disease. We discuss the relationship between these diseases of the mediastinum and the thymic microenvironment. Additionally, we suggest that a genetic predisposition for germ-cell tumors (GCT) may be involved since the parents were relatives.

KW - Chemotherapy

KW - Genetics

KW - Primary mediastinal nonseminomatous germ cell tumor

KW - Thymus microenvironment

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