Fatal liaisons of p53 with Bax and Bak

Jean Luc Perfettini; Romano T. Kroemer; Guido Kroemer

doi:10.1038/ncb0504-386

Fatal liaisons of p53 with Bax and Bak

Jean Luc Perfettini, Romano T. Kroemer, Guido Kroemer

Résultats de recherche: Contribution à un journal › !!Comment/debate

75 Citations (Scopus)

Résumé

p53 can induce apoptosis through its well defined role as a regulator of transcription, but also by a less well defined transcription-independent mechanism. Two recent studies demonstrate that p53 mediates mitochondrial permeabilization through direct physical interactions with the pro-apoptotic Bcl-2 family members, Bax and Bak.

langue originale	Anglais
Pages (de - à)	386-388
Nombre de pages	3
journal	Nature Cell Biology
Volume	6
Numéro de publication	5
Les DOIs	https://doi.org/10.1038/ncb0504-386
état	Publié - 1 mai 2004

Accès au document

10.1038/ncb0504-386

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Contient cette citation

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title = "Fatal liaisons of p53 with Bax and Bak",

abstract = "p53 can induce apoptosis through its well defined role as a regulator of transcription, but also by a less well defined transcription-independent mechanism. Two recent studies demonstrate that p53 mediates mitochondrial permeabilization through direct physical interactions with the pro-apoptotic Bcl-2 family members, Bax and Bak.",

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