FERTILITE MASCULINE APRES CHIMIOTHERAPIE DANS L'ENFANCE

F. Aubier, C. Patte, F. De Vathaire, M. F. Tournade, O. Oberlin, O. Sakiroglu, J. Lemerle

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    Résumé

    Chemotherapy has considerably improved the prognosis of solid tumours in children, but may have very adverse effects, particularly on fertility. A study was conducted at the Gustave Roussy Institute to identify the toxic effect of chemotherapy on male fertility. At present, 205 patients, treated during childhood have entered the study. Basal FSH-LH have been assayed to assess possible germ cell damage although azoosperia can not be eliminated. Results were normal in 127 patients (62%) and increased basal FSH levels were found in 78 (38%). Endocrine function was not altered: all patients were either impubertal or intrapubertal at diagnosis and subsequently achieved normal puberty. Multivariate analysis revealed an obvious toxic effect of 2 alkylating drugs: cyclophosphamide and procarbazine. No toxic effect was observed for vincristine, doxorubicin or actinomycin D. Age and pubertal status at diagnosis were not correlated with toxic effects. At present, no conclusion for other drugs may be made but results with high dose methotrexate are promising. For lomustine and cisplatin, less favourable, though non-significant, results have been obtained. Complete recovery is possible several years later.

    Titre traduit de la contributionMale fertility after chemotherapy during childhood
    langue originaleFrançais
    Pages (de - à)141-142
    Nombre de pages2
    journalAnnales d'Endocrinologie
    Volume56
    Numéro de publication2
    étatPublié - 1 janv. 1995

    mots-clés

    • alkylating drugs
    • basal FSH-LH
    • chemotherapy
    • fertility
    • recovery

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