Fertility results and oncologic outcomes in patients with stage II and III serous borderline ovarian tumors

Doris Célanie; Stéphanie Scherier; Amandine Maulard; Patricia Pautier; Alexandra Leary; Catherine Genestie; Philippe Morice; Sébastien Gouy

doi:10.1016/j.ijgc.2025.101636

Fertility results and oncologic outcomes in patients with stage II and III serous borderline ovarian tumors

Doris Célanie, Stéphanie Scherier, Amandine Maulard, Patricia Pautier, Alexandra Leary, Catherine Genestie, Philippe Morice, Sébastien Gouy

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

This retrospective study aimed to analyze the fertility results and oncologic outcomes of patients with stage II and III serous borderline ovarian tumors after fertility-sparing surgery and to seek future fertility. Among 224 patients with stage II and III serous borderline ovarian tumors treated or referred to our institution, 74 (33%) underwent fertility-sparing surgery. Median time of follow-up was 4.1 years (range; 3.2-7.9); 35 (47%) patients attempted to be pregnant and 21 (60%) had at least 1 pregnancy. Nineteen live-birth pregnancies were observed (9 spontaneously) in 18 patients (all but 1 with non-invasive implants). Seven patients had recurrent disease treated conservatively before pregnancy and 8 recurred after pregnancy (6 recurred as ovarian borderline tumors and 1 as a low-grade serous carcinoma).

langue originale	Anglais
Numéro d'article	101636
journal	International Journal of Gynecological Cancer
Volume	35
Numéro de publication	4
Les DOIs	https://doi.org/10.1016/j.ijgc.2025.101636
état	Publié - 1 avr. 2025

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10.1016/j.ijgc.2025.101636

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title = "Fertility results and oncologic outcomes in patients with stage II and III serous borderline ovarian tumors",

abstract = "This retrospective study aimed to analyze the fertility results and oncologic outcomes of patients with stage II and III serous borderline ovarian tumors after fertility-sparing surgery and to seek future fertility. Among 224 patients with stage II and III serous borderline ovarian tumors treated or referred to our institution, 74 (33%) underwent fertility-sparing surgery. Median time of follow-up was 4.1 years (range; 3.2-7.9); 35 (47%) patients attempted to be pregnant and 21 (60%) had at least 1 pregnancy. Nineteen live-birth pregnancies were observed (9 spontaneously) in 18 patients (all but 1 with non-invasive implants). Seven patients had recurrent disease treated conservatively before pregnancy and 8 recurred after pregnancy (6 recurred as ovarian borderline tumors and 1 as a low-grade serous carcinoma).",

keywords = "Borderline Tumor, Fertility, IVF, Ovarian Tumor, Prognosis, Recurrence",

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T1 - Fertility results and oncologic outcomes in patients with stage II and III serous borderline ovarian tumors

AU - Célanie, Doris

AU - Scherier, Stéphanie

AU - Maulard, Amandine

AU - Pautier, Patricia

AU - Leary, Alexandra

AU - Genestie, Catherine

AU - Morice, Philippe

AU - Gouy, Sébastien

PY - 2025/4/1

Y1 - 2025/4/1

N2 - This retrospective study aimed to analyze the fertility results and oncologic outcomes of patients with stage II and III serous borderline ovarian tumors after fertility-sparing surgery and to seek future fertility. Among 224 patients with stage II and III serous borderline ovarian tumors treated or referred to our institution, 74 (33%) underwent fertility-sparing surgery. Median time of follow-up was 4.1 years (range; 3.2-7.9); 35 (47%) patients attempted to be pregnant and 21 (60%) had at least 1 pregnancy. Nineteen live-birth pregnancies were observed (9 spontaneously) in 18 patients (all but 1 with non-invasive implants). Seven patients had recurrent disease treated conservatively before pregnancy and 8 recurred after pregnancy (6 recurred as ovarian borderline tumors and 1 as a low-grade serous carcinoma).

AB - This retrospective study aimed to analyze the fertility results and oncologic outcomes of patients with stage II and III serous borderline ovarian tumors after fertility-sparing surgery and to seek future fertility. Among 224 patients with stage II and III serous borderline ovarian tumors treated or referred to our institution, 74 (33%) underwent fertility-sparing surgery. Median time of follow-up was 4.1 years (range; 3.2-7.9); 35 (47%) patients attempted to be pregnant and 21 (60%) had at least 1 pregnancy. Nineteen live-birth pregnancies were observed (9 spontaneously) in 18 patients (all but 1 with non-invasive implants). Seven patients had recurrent disease treated conservatively before pregnancy and 8 recurred after pregnancy (6 recurred as ovarian borderline tumors and 1 as a low-grade serous carcinoma).

KW - Borderline Tumor

KW - Fertility

KW - IVF

KW - Ovarian Tumor

KW - Prognosis

KW - Recurrence

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