FGF receptor genes and breast cancer susceptibility: Results from the Breast Cancer Association Consortium

D. Agarwal; S. Pineda; K. Michailidou; J. Herranz; G. Pita; L. T. Moreno; M. R. Alonso; J. Dennis; Q. Wang; M. K. Bolla; K. B. Meyer; P. Menéndez-Rodríguez; D. Hardisson; M. Mendiola; A. González-Neira; A. Lindblom; S. Margolin; A. Swerdlow; A. Ashworth; N. Orr; M. Jones; K. Matsuo; H. Ito; H. Iwata; N. Kondo; M. Hartman; M. Hui; W. Y. Lim; P. T.C. Iau; E. Sawyer; I. Tomlinson; M. Kerin; N. Miller; D. Kang; J. Y. Choi; S. Park; D. Y. Noh; J. L. Hopper; D. F. Schmidt; E. Makalic; M. C. Southey; S. H. Teo; C. H. Yip; K. Sivanandan; W. T. Tay; H. Brauch; T. Brüning; U. Hamann; A. M. Dunning; M. Shah; I. L. Andrulis; J. A. Knight; G. Glendon; S. Tchatchou; M. K. Schmidt; A. Broeks; E. H. Rosenberg; L. J. van't Veer; P. A. Fasching; S. P. Renner; A. B. Ekici; M. W. Beckmann; C. Y. Shen; C. N. Hsiung; J. C. Yu; M. F. Hou; W. Blot; Q. Cai; A. H. Wu; C. C. Tseng; D. Van Den Berg; D. O. Stram; A. Cox; I. W. Brock; M. W.R. Reed; K. Muir; A. Lophatananon; S. Stewart-Brown; P. Siriwanarangsan; W. Zheng; S. Deming-Halverson; M. J. Shrubsole; J. Long; X. O. Shu; W. Lu; Y. T. Gao; B. Zhang; P. Radice; P. Peterlongo; S. Manoukian; F. Mariette; S. Sangrajrang; J. McKay; F. J. Couch; A. E. Toland; D. Yannoukakos; O. Fletcher; N. Johnson; I. Dos Santos Silva; J. Peto; F. Marme; B. Burwinkel; P. Guénel; T. Truong; M. Sanchez; C. Mulot; S. E. Bojesen; B. G. Nordestgaard; H. Flyer; H. Brenner; A. K. Dieffenbach; V. Arndt; C. Stegmaier; A. Mannermaa; V. Kataja; V. M. Kosma; J. M. Hartikainen; D. Lambrechts; B. T. Yesilyurt; G. Floris; K. Leunen; J. Chang-Claude; A. Rudolph; P. Seibold; D. Flesch-Janys; X. Wang; J. E. Olson; C. Vachon; K. Purrington; G. G. Giles; G. Severi; L. Baglietto; C. A. Haiman; B. E. Henderson; F. Schumacher; L. Le Marchand; J. Simard; M. Dumont; M. S. Goldberg; F. Labrèche; R. Winqvist; K. Pylkäs; A. Jukkola-Vuorinen; M. Grip; P. Devilee; R. A. E M Tollenaar; C. Seynaeve; M. García-Closas; S. J. Chanock; J. Lissowska; J. D. Figueroa; K. Czene; M. Eriksson; K. Humphreys; H. Darabi; M. J. Hooning; M. Kriege; J. M. Collée; M. Tilanus-Linthorst; J. Li; A. Jakubowska; J. Lubinski; K. Jaworska-Bieniek; K. Durda; H. Nevanlinna; T. A. Muranen; K. Aittomäki; C. Blomqvist; N. Bogdanova; T. Dörk; P. Hall; G. Chenevix-Trench; D. F. Easton; P. D. P Pharoah; J. I. Arias-Perez; P. Zamora; J. Benítez; R. L. Milne

doi:10.1038/bjc.2013.769

FGF receptor genes and breast cancer susceptibility: Results from the Breast Cancer Association Consortium

D. Agarwal, S. Pineda, K. Michailidou, J. Herranz, G. Pita, L. T. Moreno, M. R. Alonso, J. Dennis, Q. Wang, M. K. Bolla, K. B. Meyer, P. Menéndez-Rodríguez, D. Hardisson, M. Mendiola, A. González-Neira, A. Lindblom, S. Margolin, A. Swerdlow, A. Ashworth, N. OrrM. Jones, K. Matsuo, H. Ito, H. Iwata, N. Kondo, M. Hartman, M. Hui, W. Y. Lim, P. T.C. Iau, E. Sawyer, I. Tomlinson, M. Kerin, N. Miller, D. Kang, J. Y. Choi, S. Park, D. Y. Noh, J. L. Hopper, D. F. Schmidt, E. Makalic, M. C. Southey, S. H. Teo, C. H. Yip, K. Sivanandan, W. T. Tay, H. Brauch, T. Brüning, U. Hamann, A. M. Dunning, M. Shah, I. L. Andrulis, J. A. Knight, G. Glendon, S. Tchatchou, M. K. Schmidt, A. Broeks, E. H. Rosenberg, L. J. van't Veer, P. A. Fasching, S. P. Renner, A. B. Ekici, M. W. Beckmann, C. Y. Shen, C. N. Hsiung, J. C. Yu, M. F. Hou, W. Blot, Q. Cai, A. H. Wu, C. C. Tseng, D. Van Den Berg, D. O. Stram, A. Cox, I. W. Brock, M. W.R. Reed, K. Muir, A. Lophatananon, S. Stewart-Brown, P. Siriwanarangsan, W. Zheng, S. Deming-Halverson, M. J. Shrubsole, J. Long, X. O. Shu, W. Lu, Y. T. Gao, B. Zhang, P. Radice, P. Peterlongo, S. Manoukian, F. Mariette, S. Sangrajrang, J. McKay, F. J. Couch, A. E. Toland, D. Yannoukakos, O. Fletcher, N. Johnson, I. Dos Santos Silva, J. Peto, F. Marme, B. Burwinkel, P. Guénel, T. Truong, M. Sanchez, C. Mulot, S. E. Bojesen, B. G. Nordestgaard, H. Flyer, H. Brenner, A. K. Dieffenbach, V. Arndt, C. Stegmaier, A. Mannermaa, V. Kataja, V. M. Kosma, J. M. Hartikainen, D. Lambrechts, B. T. Yesilyurt, G. Floris, K. Leunen, J. Chang-Claude, A. Rudolph, P. Seibold, D. Flesch-Janys, X. Wang, J. E. Olson, C. Vachon, K. Purrington, G. G. Giles, G. Severi, L. Baglietto, C. A. Haiman, B. E. Henderson, F. Schumacher, L. Le Marchand, J. Simard, M. Dumont, M. S. Goldberg, F. Labrèche, R. Winqvist, K. Pylkäs, A. Jukkola-Vuorinen, M. Grip, P. Devilee, R. A. E M Tollenaar, C. Seynaeve, M. García-Closas, S. J. Chanock, J. Lissowska, J. D. Figueroa, K. Czene, M. Eriksson, K. Humphreys, H. Darabi, M. J. Hooning, M. Kriege, J. M. Collée, M. Tilanus-Linthorst, J. Li, A. Jakubowska, J. Lubinski, K. Jaworska-Bieniek, K. Durda, H. Nevanlinna, T. A. Muranen, K. Aittomäki, C. Blomqvist, N. Bogdanova, T. Dörk, P. Hall, G. Chenevix-Trench, D. F. Easton, P. D. P Pharoah, J. I. Arias-Perez, P. Zamora, J. Benítez, R. L. Milne

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

23 Citations (Scopus)

Résumé

Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.Methods:Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.Results:Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2.Conclusion:Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2.

langue originale	Anglais
Pages (de - à)	1088-1100
Nombre de pages	13
journal	British Journal of Cancer
Volume	110
Numéro de publication	4
Les DOIs	https://doi.org/10.1038/bjc.2013.769
état	Publié - 18 févr. 2014
Modification externe	Oui

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10.1038/bjc.2013.769

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Agarwal, D., Pineda, S., Michailidou, K., Herranz, J., Pita, G., Moreno, L. T., Alonso, M. R., Dennis, J., Wang, Q., Bolla, M. K., Meyer, K. B., Menéndez-Rodríguez, P., Hardisson, D., Mendiola, M., González-Neira, A., Lindblom, A., Margolin, S., Swerdlow, A., Ashworth, A., ... Milne, R. L. (2014). FGF receptor genes and breast cancer susceptibility: Results from the Breast Cancer Association Consortium. British Journal of Cancer, 110(4), 1088-1100. https://doi.org/10.1038/bjc.2013.769

@article{e4f68b43914f436ba9ba32d7c3394441,

title = "FGF receptor genes and breast cancer susceptibility: Results from the Breast Cancer Association Consortium",

abstract = "Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.Methods:Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.Results:Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2.Conclusion:Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2.",

author = "D. Agarwal and S. Pineda and K. Michailidou and J. Herranz and G. Pita and Moreno, {L. T.} and Alonso, {M. R.} and J. Dennis and Q. Wang and Bolla, {M. K.} and Meyer, {K. B.} and P. Men{\'e}ndez-Rodr{\'i}guez and D. Hardisson and M. Mendiola and A. Gonz{\'a}lez-Neira and A. Lindblom and S. Margolin and A. Swerdlow and A. Ashworth and N. Orr and M. Jones and K. Matsuo and H. Ito and H. Iwata and N. Kondo and M. Hartman and M. Hui and Lim, {W. Y.} and Iau, {P. T.C.} and E. Sawyer and I. Tomlinson and M. Kerin and N. Miller and D. Kang and Choi, {J. Y.} and S. Park and Noh, {D. Y.} and Hopper, {J. L.} and Schmidt, {D. F.} and E. Makalic and Southey, {M. C.} and Teo, {S. H.} and Yip, {C. H.} and K. Sivanandan and Tay, {W. T.} and H. Brauch and T. Br{\"u}ning and U. Hamann and Dunning, {A. M.} and M. Shah and Andrulis, {I. L.} and Knight, {J. A.} and G. Glendon and S. Tchatchou and Schmidt, {M. K.} and A. Broeks and Rosenberg, {E. H.} and {van't Veer}, {L. J.} and Fasching, {P. A.} and Renner, {S. P.} and Ekici, {A. B.} and Beckmann, {M. W.} and Shen, {C. Y.} and Hsiung, {C. N.} and Yu, {J. C.} and Hou, {M. F.} and W. Blot and Q. Cai and Wu, {A. H.} and Tseng, {C. C.} and {Van Den Berg}, D. and Stram, {D. O.} and A. Cox and Brock, {I. W.} and Reed, {M. W.R.} and K. Muir and A. Lophatananon and S. Stewart-Brown and P. Siriwanarangsan and W. Zheng and S. Deming-Halverson and Shrubsole, {M. J.} and J. Long and Shu, {X. O.} and W. Lu and Gao, {Y. T.} and B. Zhang and P. Radice and P. Peterlongo and S. Manoukian and F. Mariette and S. Sangrajrang and J. McKay and Couch, {F. J.} and Toland, {A. E.} and D. Yannoukakos and O. Fletcher and N. Johnson and {Dos Santos Silva}, I. and J. Peto and F. Marme and B. Burwinkel and P. Gu{\'e}nel and T. Truong and M. Sanchez and C. Mulot and Bojesen, {S. E.} and Nordestgaard, {B. G.} and H. Flyer and H. Brenner and Dieffenbach, {A. K.} and V. Arndt and C. Stegmaier and A. Mannermaa and V. Kataja and Kosma, {V. M.} and Hartikainen, {J. M.} and D. Lambrechts and Yesilyurt, {B. T.} and G. Floris and K. Leunen and J. Chang-Claude and A. Rudolph and P. Seibold and D. Flesch-Janys and X. Wang and Olson, {J. E.} and C. Vachon and K. Purrington and Giles, {G. G.} and G. Severi and L. Baglietto and Haiman, {C. A.} and Henderson, {B. E.} and F. Schumacher and {Le Marchand}, L. and J. Simard and M. Dumont and Goldberg, {M. S.} and F. Labr{\`e}che and R. Winqvist and K. Pylk{\"a}s and A. Jukkola-Vuorinen and M. Grip and P. Devilee and {E M Tollenaar}, {R. A.} and C. Seynaeve and M. Garc{\'i}a-Closas and Chanock, {S. J.} and J. Lissowska and Figueroa, {J. D.} and K. Czene and M. Eriksson and K. Humphreys and H. Darabi and Hooning, {M. J.} and M. Kriege and Coll{\'e}e, {J. M.} and M. Tilanus-Linthorst and J. Li and A. Jakubowska and J. Lubinski and K. Jaworska-Bieniek and K. Durda and H. Nevanlinna and Muranen, {T. A.} and K. Aittom{\"a}ki and C. Blomqvist and N. Bogdanova and T. D{\"o}rk and P. Hall and G. Chenevix-Trench and Easton, {D. F.} and {P Pharoah}, {P. D.} and Arias-Perez, {J. I.} and P. Zamora and J. Ben{\'i}tez and Milne, {R. L.}",

year = "2014",

month = feb,

day = "18",

doi = "10.1038/bjc.2013.769",

language = "English",

volume = "110",

pages = "1088--1100",

journal = "British Journal of Cancer",

issn = "0007-0920",

number = "4",

}

Agarwal, D, Pineda, S, Michailidou, K, Herranz, J, Pita, G, Moreno, LT, Alonso, MR, Dennis, J, Wang, Q, Bolla, MK, Meyer, KB, Menéndez-Rodríguez, P, Hardisson, D, Mendiola, M, González-Neira, A, Lindblom, A, Margolin, S, Swerdlow, A, Ashworth, A, Orr, N, Jones, M, Matsuo, K, Ito, H, Iwata, H, Kondo, N, Hartman, M, Hui, M, Lim, WY, Iau, PTC, Sawyer, E, Tomlinson, I, Kerin, M, Miller, N, Kang, D, Choi, JY, Park, S, Noh, DY, Hopper, JL, Schmidt, DF, Makalic, E, Southey, MC, Teo, SH, Yip, CH, Sivanandan, K, Tay, WT, Brauch, H, Brüning, T, Hamann, U, Dunning, AM, Shah, M, Andrulis, IL, Knight, JA, Glendon, G, Tchatchou, S, Schmidt, MK, Broeks, A, Rosenberg, EH, van't Veer, LJ, Fasching, PA, Renner, SP, Ekici, AB, Beckmann, MW, Shen, CY, Hsiung, CN, Yu, JC, Hou, MF, Blot, W, Cai, Q, Wu, AH, Tseng, CC, Van Den Berg, D, Stram, DO, Cox, A, Brock, IW, Reed, MWR, Muir, K, Lophatananon, A, Stewart-Brown, S, Siriwanarangsan, P, Zheng, W, Deming-Halverson, S, Shrubsole, MJ, Long, J, Shu, XO, Lu, W, Gao, YT, Zhang, B, Radice, P, Peterlongo, P, Manoukian, S, Mariette, F, Sangrajrang, S, McKay, J, Couch, FJ, Toland, AE, Yannoukakos, D, Fletcher, O, Johnson, N, Dos Santos Silva, I, Peto, J, Marme, F, Burwinkel, B, Guénel, P, Truong, T, Sanchez, M, Mulot, C, Bojesen, SE, Nordestgaard, BG, Flyer, H, Brenner, H, Dieffenbach, AK, Arndt, V, Stegmaier, C, Mannermaa, A, Kataja, V, Kosma, VM, Hartikainen, JM, Lambrechts, D, Yesilyurt, BT, Floris, G, Leunen, K, Chang-Claude, J, Rudolph, A, Seibold, P, Flesch-Janys, D, Wang, X, Olson, JE, Vachon, C, Purrington, K, Giles, GG, Severi, G, Baglietto, L, Haiman, CA, Henderson, BE, Schumacher, F, Le Marchand, L, Simard, J, Dumont, M, Goldberg, MS, Labrèche, F, Winqvist, R, Pylkäs, K, Jukkola-Vuorinen, A, Grip, M, Devilee, P, E M Tollenaar, RA, Seynaeve, C, García-Closas, M, Chanock, SJ, Lissowska, J, Figueroa, JD, Czene, K, Eriksson, M, Humphreys, K, Darabi, H, Hooning, MJ, Kriege, M, Collée, JM, Tilanus-Linthorst, M, Li, J, Jakubowska, A, Lubinski, J, Jaworska-Bieniek, K, Durda, K, Nevanlinna, H, Muranen, TA, Aittomäki, K, Blomqvist, C, Bogdanova, N, Dörk, T, Hall, P, Chenevix-Trench, G, Easton, DF, P Pharoah, PD, Arias-Perez, JI, Zamora, P, Benítez, J & Milne, RL 2014, 'FGF receptor genes and breast cancer susceptibility: Results from the Breast Cancer Association Consortium', British Journal of Cancer, VOL. 110, Numéro 4, p. 1088-1100. https://doi.org/10.1038/bjc.2013.769

TY - JOUR

T1 - FGF receptor genes and breast cancer susceptibility

T2 - Results from the Breast Cancer Association Consortium

AU - Agarwal, D.

AU - Pineda, S.

AU - Michailidou, K.

AU - Herranz, J.

AU - Pita, G.

AU - Moreno, L. T.

AU - Alonso, M. R.

AU - Dennis, J.

AU - Wang, Q.

AU - Bolla, M. K.

AU - Meyer, K. B.

AU - Menéndez-Rodríguez, P.

AU - Hardisson, D.

AU - Mendiola, M.

AU - González-Neira, A.

AU - Lindblom, A.

AU - Margolin, S.

AU - Swerdlow, A.

AU - Ashworth, A.

AU - Orr, N.

AU - Jones, M.

AU - Matsuo, K.

AU - Ito, H.

AU - Iwata, H.

AU - Kondo, N.

AU - Hartman, M.

AU - Hui, M.

AU - Lim, W. Y.

AU - Iau, P. T.C.

AU - Sawyer, E.

AU - Tomlinson, I.

AU - Kerin, M.

AU - Miller, N.

AU - Kang, D.

AU - Choi, J. Y.

AU - Park, S.

AU - Noh, D. Y.

AU - Hopper, J. L.

AU - Schmidt, D. F.

AU - Makalic, E.

AU - Southey, M. C.

AU - Teo, S. H.

AU - Yip, C. H.

AU - Sivanandan, K.

AU - Tay, W. T.

AU - Brauch, H.

AU - Brüning, T.

AU - Hamann, U.

AU - Dunning, A. M.

AU - Shah, M.

AU - Andrulis, I. L.

AU - Knight, J. A.

AU - Glendon, G.

AU - Tchatchou, S.

AU - Schmidt, M. K.

AU - Broeks, A.

AU - Rosenberg, E. H.

AU - van't Veer, L. J.

AU - Fasching, P. A.

AU - Renner, S. P.

AU - Ekici, A. B.

AU - Beckmann, M. W.

AU - Shen, C. Y.

AU - Hsiung, C. N.

AU - Yu, J. C.

AU - Hou, M. F.

AU - Blot, W.

AU - Cai, Q.

AU - Wu, A. H.

AU - Tseng, C. C.

AU - Van Den Berg, D.

AU - Stram, D. O.

AU - Cox, A.

AU - Brock, I. W.

AU - Reed, M. W.R.

AU - Muir, K.

AU - Lophatananon, A.

AU - Stewart-Brown, S.

AU - Siriwanarangsan, P.

AU - Zheng, W.

AU - Deming-Halverson, S.

AU - Shrubsole, M. J.

AU - Long, J.

AU - Shu, X. O.

AU - Lu, W.

AU - Gao, Y. T.

AU - Zhang, B.

AU - Radice, P.

AU - Peterlongo, P.

AU - Manoukian, S.

AU - Mariette, F.

AU - Sangrajrang, S.

AU - McKay, J.

AU - Couch, F. J.

AU - Toland, A. E.

AU - Yannoukakos, D.

AU - Fletcher, O.

AU - Johnson, N.

AU - Dos Santos Silva, I.

AU - Peto, J.

AU - Marme, F.

AU - Burwinkel, B.

AU - Guénel, P.

AU - Truong, T.

AU - Sanchez, M.

AU - Mulot, C.

AU - Bojesen, S. E.

AU - Nordestgaard, B. G.

AU - Flyer, H.

AU - Brenner, H.

AU - Dieffenbach, A. K.

AU - Arndt, V.

AU - Stegmaier, C.

AU - Mannermaa, A.

AU - Kataja, V.

AU - Kosma, V. M.

AU - Hartikainen, J. M.

AU - Lambrechts, D.

AU - Yesilyurt, B. T.

AU - Floris, G.

AU - Leunen, K.

AU - Chang-Claude, J.

AU - Rudolph, A.

AU - Seibold, P.

AU - Flesch-Janys, D.

AU - Wang, X.

AU - Olson, J. E.

AU - Vachon, C.

AU - Purrington, K.

AU - Giles, G. G.

AU - Severi, G.

AU - Baglietto, L.

AU - Haiman, C. A.

AU - Henderson, B. E.

AU - Schumacher, F.

AU - Le Marchand, L.

AU - Simard, J.

AU - Dumont, M.

AU - Goldberg, M. S.

AU - Labrèche, F.

AU - Winqvist, R.

AU - Pylkäs, K.

AU - Jukkola-Vuorinen, A.

AU - Grip, M.

AU - Devilee, P.

AU - E M Tollenaar, R. A.

AU - Seynaeve, C.

AU - García-Closas, M.

AU - Chanock, S. J.

AU - Lissowska, J.

AU - Figueroa, J. D.

AU - Czene, K.

AU - Eriksson, M.

AU - Humphreys, K.

AU - Darabi, H.

AU - Hooning, M. J.

AU - Kriege, M.

AU - Collée, J. M.

AU - Tilanus-Linthorst, M.

AU - Li, J.

AU - Jakubowska, A.

AU - Lubinski, J.

AU - Jaworska-Bieniek, K.

AU - Durda, K.

AU - Nevanlinna, H.

AU - Muranen, T. A.

AU - Aittomäki, K.

AU - Blomqvist, C.

AU - Bogdanova, N.

AU - Dörk, T.

AU - Hall, P.

AU - Chenevix-Trench, G.

AU - Easton, D. F.

AU - P Pharoah, P. D.

AU - Arias-Perez, J. I.

AU - Zamora, P.

AU - Benítez, J.

AU - Milne, R. L.

PY - 2014/2/18

Y1 - 2014/2/18

N2 - Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.Methods:Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.Results:Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2.Conclusion:Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2.

AB - Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.Methods:Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.Results:Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2.Conclusion:Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2.

UR - http://www.scopus.com/inward/record.url?scp=84894304619&partnerID=8YFLogxK

U2 - 10.1038/bjc.2013.769

DO - 10.1038/bjc.2013.769

M3 - Article

C2 - 24548884

AN - SCOPUS:84894304619

SN - 0007-0920

VL - 110

SP - 1088

EP - 1100

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 4

ER -