First-line immune checkpoint blockade for advanced non-small-cell lung cancer: Travelling at the speed of light

Christoph Jakob Ackermann; Martin Reck; Luis Paz-Ares; Fabrice Barlesi; Raffaele Califano

doi:10.1016/j.lungcan.2019.06.007

First-line immune checkpoint blockade for advanced non-small-cell lung cancer: Travelling at the speed of light

Christoph Jakob Ackermann, Martin Reck, Luis Paz-Ares, Fabrice Barlesi, Raffaele Califano

Résultats de recherche: Contribution à un journal › Article 'review' › Revue par des pairs

33 Citations (Scopus)

Résumé

The development of PD-1, PD-L1 and CTLA-4 immune checkpoint inhibitors (CPI) has revolutionised the treatment of advanced non-small cell lung cancer (NSCLC). The potential of immunotherapy (IO) to induce durable responses for a subset of patients represents a therapeutic milestone. After the approval of front-line single agent pembrolizumab, IO-based combinations are rapidly entering clinical practice resulting in a fast change of treatment algorithms for advanced NSCLC. We hereby summarize the recent first-line phase 3 trials evaluating PD-(L)1 blockade plus chemotherapy (ChT) and PD-1 plus CTLA-4 CPI for advanced NSCLC and provide potential treatment recommendations.

langue originale	Anglais
Pages (de - à)	245-253
Nombre de pages	9
journal	Lung Cancer
Volume	134
Les DOIs	https://doi.org/10.1016/j.lungcan.2019.06.007
état	Publié - 1 août 2019
Modification externe	Oui

Accès au document

10.1016/j.lungcan.2019.06.007

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title = "First-line immune checkpoint blockade for advanced non-small-cell lung cancer: Travelling at the speed of light",

abstract = "The development of PD-1, PD-L1 and CTLA-4 immune checkpoint inhibitors (CPI) has revolutionised the treatment of advanced non-small cell lung cancer (NSCLC). The potential of immunotherapy (IO) to induce durable responses for a subset of patients represents a therapeutic milestone. After the approval of front-line single agent pembrolizumab, IO-based combinations are rapidly entering clinical practice resulting in a fast change of treatment algorithms for advanced NSCLC. We hereby summarize the recent first-line phase 3 trials evaluating PD-(L)1 blockade plus chemotherapy (ChT) and PD-1 plus CTLA-4 CPI for advanced NSCLC and provide potential treatment recommendations.",

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AU - Barlesi, Fabrice

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