Fondements moléculaires de la translocation t(1;22)(p13;q13) des leucémies aiguës à mégacaryoblastes

T. Mercher; G. Courtois; R. Berger; O. A. Bernard

doi:10.1016/S0369-8114(02)00354-1

Fondements moléculaires de la translocation t(1;22)(p13;q13) des leucémies aiguës à mégacaryoblastes

T. Mercher, G. Courtois, R. Berger, O. A. Bernard

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Résumé

The t(1;22)(p13;q13) translocation is specifically associated with infant acute megakaryoblastic leukemia (M7). We have recently characterized the two genes involved in this translocation: OTT (One Two Two) and MAL (Megakaryoblastic Acute Leukemia) respectively located on chromosome 1 and 22. The t(1;22) translocation results in the fusion of these genes in all the cases studied to date. We summarize here present knowledge regarding this translocation.

Titre traduit de la contribution	Molecular basis of the t(1;22)(p13;q13) specific for human acute megakaryoblastic leukemia
langue originale	Français
Pages (de - à)	27-32
Nombre de pages	6
journal	Pathologie Biologie
Volume	51
Numéro de publication	1
Les DOIs	https://doi.org/10.1016/S0369-8114(02)00354-1
état	Publié - 1 janv. 2003

mots-clés

AML
Fusion
MAL
Megakaryoblast
OTT
Translocation

Accès au document

10.1016/S0369-8114(02)00354-1

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abstract = "The t(1;22)(p13;q13) translocation is specifically associated with infant acute megakaryoblastic leukemia (M7). We have recently characterized the two genes involved in this translocation: OTT (One Two Two) and MAL (Megakaryoblastic Acute Leukemia) respectively located on chromosome 1 and 22. The t(1;22) translocation results in the fusion of these genes in all the cases studied to date. We summarize here present knowledge regarding this translocation.",

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AU - Mercher, T.

AU - Courtois, G.

AU - Berger, R.

AU - Bernard, O. A.

PY - 2003/1/1

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N2 - The t(1;22)(p13;q13) translocation is specifically associated with infant acute megakaryoblastic leukemia (M7). We have recently characterized the two genes involved in this translocation: OTT (One Two Two) and MAL (Megakaryoblastic Acute Leukemia) respectively located on chromosome 1 and 22. The t(1;22) translocation results in the fusion of these genes in all the cases studied to date. We summarize here present knowledge regarding this translocation.

AB - The t(1;22)(p13;q13) translocation is specifically associated with infant acute megakaryoblastic leukemia (M7). We have recently characterized the two genes involved in this translocation: OTT (One Two Two) and MAL (Megakaryoblastic Acute Leukemia) respectively located on chromosome 1 and 22. The t(1;22) translocation results in the fusion of these genes in all the cases studied to date. We summarize here present knowledge regarding this translocation.

KW - AML

KW - Fusion

KW - MAL

KW - Megakaryoblast

KW - OTT

KW - Translocation

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