TY - JOUR
T1 - Functional characterization of human thyroid tissue with immunohistochemistry
AU - Faggiano, Antongiulio
AU - Caillou, Bernard
AU - Lacroix, Ludovic
AU - Talbot, Monique
AU - Filetti, Sebastiano
AU - Bidart, Jean Michel
AU - Schlumberger, Martin
PY - 2007/3/1
Y1 - 2007/3/1
N2 - Immunohistochemistry provides insights in the expression of functional proteins and of their localization in normal thyroid tissue and in thyroid diseases. In hyperfunctional thyroid tissues, staining for sodium/iodide symporter (NIS), pendrin, thyroid peroxidase (TPO), and thyroglobulin (Tg) is increased. In hypofunctioning thyroid tissues, NIS staining is markedly decreased; in benign hypofunctioning adenomas, the expression of the other functional proteins is unmodified or slightly decreased, whereas their expression is profoundly decreased or absent in differentiated thyroid carcinoma.
AB - Immunohistochemistry provides insights in the expression of functional proteins and of their localization in normal thyroid tissue and in thyroid diseases. In hyperfunctional thyroid tissues, staining for sodium/iodide symporter (NIS), pendrin, thyroid peroxidase (TPO), and thyroglobulin (Tg) is increased. In hypofunctioning thyroid tissues, NIS staining is markedly decreased; in benign hypofunctioning adenomas, the expression of the other functional proteins is unmodified or slightly decreased, whereas their expression is profoundly decreased or absent in differentiated thyroid carcinoma.
UR - http://www.scopus.com/inward/record.url?scp=34147095931&partnerID=8YFLogxK
U2 - 10.1089/thy.2006.0174
DO - 10.1089/thy.2006.0174
M3 - Article
C2 - 17381352
AN - SCOPUS:34147095931
SN - 1050-7256
VL - 17
SP - 203
EP - 211
JO - Thyroid
JF - Thyroid
IS - 3
ER -