Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

Catherine S. Grasso; Yujie Tang; Nathalene Truffaux; Noah E. Berlow; Lining Liu; Marie Anne Debily; Michael J. Quist; Lara E. Davis; Elaine C. Huang; Pamelyn J. Woo; Anitha Ponnuswami; Spenser Chen; Tessa B. Johung; Wenchao Sun; Mari Kogiso; Yuchen Du; Lin Qi; Yulun Huang; Marianne Hütt-Cabezas; Katherine E. Warren; Ludivine Le Dret; Paul S. Meltzer; Hua Mao; Martha Quezado; Dannis G. Van Vuurden; Jinu Abraham; Maryam Fouladi; Matthew N. Svalina; Nicholas Wang; Cynthia Hawkins; Javad Nazarian; Marta M. Alonso; Eric H. Raabe; Esther Hulleman; Paul T. Spellman; Xiao Nan Li; Charles Keller; Ranadip Pal; Jacques Grill; Michelle Monje

doi:10.1038/nm.3855

Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

Catherine S. Grasso, Yujie Tang, Nathalene Truffaux, Noah E. Berlow, Lining Liu, Marie Anne Debily, Michael J. Quist, Lara E. Davis, Elaine C. Huang, Pamelyn J. Woo, Anitha Ponnuswami, Spenser Chen, Tessa B. Johung, Wenchao Sun, Mari Kogiso, Yuchen Du, Lin Qi, Yulun Huang, Marianne Hütt-Cabezas, Katherine E. WarrenLudivine Le Dret, Paul S. Meltzer, Hua Mao, Martha Quezado, Dannis G. Van Vuurden, Jinu Abraham, Maryam Fouladi, Matthew N. Svalina, Nicholas Wang, Cynthia Hawkins, Javad Nazarian, Marta M. Alonso, Eric H. Raabe, Esther Hulleman, Paul T. Spellman, Xiao Nan Li, Charles Keller, Ranadip Pal, Jacques Grill, Michelle Monje

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

443 Citations (Scopus)

Résumé

Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor panobinostat demonstrated therapeutic efficacy both in vitro and in DIPG orthotopic xenograft models. Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the two had synergistic effects. Together, these data suggest a promising therapeutic strategy for DIPG.

langue originale	Anglais
Pages (de - à)	555-559
Nombre de pages	5
journal	Nature Medicine
Volume	21
Numéro de publication	6
Les DOIs	https://doi.org/10.1038/nm.3855
état	Publié - 9 juin 2015

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10.1038/nm.3855

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Grasso, C. S., Tang, Y., Truffaux, N., Berlow, N. E., Liu, L., Debily, M. A., Quist, M. J., Davis, L. E., Huang, E. C., Woo, P. J., Ponnuswami, A., Chen, S., Johung, T. B., Sun, W., Kogiso, M., Du, Y., Qi, L., Huang, Y., Hütt-Cabezas, M., ... Monje, M. (2015). Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. Nature Medicine, 21(6), 555-559. https://doi.org/10.1038/nm.3855

@article{3dae39d1c9714185ad35cc211bd99821,

title = "Functionally defined therapeutic targets in diffuse intrinsic pontine glioma",

abstract = "Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor panobinostat demonstrated therapeutic efficacy both in vitro and in DIPG orthotopic xenograft models. Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the two had synergistic effects. Together, these data suggest a promising therapeutic strategy for DIPG.",

author = "Grasso, {Catherine S.} and Yujie Tang and Nathalene Truffaux and Berlow, {Noah E.} and Lining Liu and Debily, {Marie Anne} and Quist, {Michael J.} and Davis, {Lara E.} and Huang, {Elaine C.} and Woo, {Pamelyn J.} and Anitha Ponnuswami and Spenser Chen and Johung, {Tessa B.} and Wenchao Sun and Mari Kogiso and Yuchen Du and Lin Qi and Yulun Huang and Marianne H{\"u}tt-Cabezas and Warren, {Katherine E.} and {Le Dret}, Ludivine and Meltzer, {Paul S.} and Hua Mao and Martha Quezado and {Van Vuurden}, {Dannis G.} and Jinu Abraham and Maryam Fouladi and Svalina, {Matthew N.} and Nicholas Wang and Cynthia Hawkins and Javad Nazarian and Alonso, {Marta M.} and Raabe, {Eric H.} and Esther Hulleman and Spellman, {Paul T.} and Li, {Xiao Nan} and Charles Keller and Ranadip Pal and Jacques Grill and Michelle Monje",

year = "2015",

month = jun,

day = "9",

doi = "10.1038/nm.3855",

language = "English",

volume = "21",

pages = "555--559",

journal = "Nature Medicine",

issn = "1078-8956",

number = "6",

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Grasso, CS, Tang, Y, Truffaux, N, Berlow, NE, Liu, L, Debily, MA, Quist, MJ, Davis, LE, Huang, EC, Woo, PJ, Ponnuswami, A, Chen, S, Johung, TB, Sun, W, Kogiso, M, Du, Y, Qi, L, Huang, Y, Hütt-Cabezas, M, Warren, KE, Le Dret, L, Meltzer, PS, Mao, H, Quezado, M, Van Vuurden, DG, Abraham, J, Fouladi, M, Svalina, MN, Wang, N, Hawkins, C, Nazarian, J, Alonso, MM, Raabe, EH, Hulleman, E, Spellman, PT, Li, XN, Keller, C, Pal, R, Grill, J & Monje, M 2015, 'Functionally defined therapeutic targets in diffuse intrinsic pontine glioma', Nature Medicine, VOL. 21, Numéro 6, p. 555-559. https://doi.org/10.1038/nm.3855

TY - JOUR

T1 - Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

AU - Grasso, Catherine S.

AU - Tang, Yujie

AU - Truffaux, Nathalene

AU - Berlow, Noah E.

AU - Liu, Lining

AU - Debily, Marie Anne

AU - Quist, Michael J.

AU - Davis, Lara E.

AU - Huang, Elaine C.

AU - Woo, Pamelyn J.

AU - Ponnuswami, Anitha

AU - Chen, Spenser

AU - Johung, Tessa B.

AU - Sun, Wenchao

AU - Kogiso, Mari

AU - Du, Yuchen

AU - Qi, Lin

AU - Huang, Yulun

AU - Hütt-Cabezas, Marianne

AU - Warren, Katherine E.

AU - Le Dret, Ludivine

AU - Meltzer, Paul S.

AU - Mao, Hua

AU - Quezado, Martha

AU - Van Vuurden, Dannis G.

AU - Abraham, Jinu

AU - Fouladi, Maryam

AU - Svalina, Matthew N.

AU - Wang, Nicholas

AU - Hawkins, Cynthia

AU - Nazarian, Javad

AU - Alonso, Marta M.

AU - Raabe, Eric H.

AU - Hulleman, Esther

AU - Spellman, Paul T.

AU - Li, Xiao Nan

AU - Keller, Charles

AU - Pal, Ranadip

AU - Grill, Jacques

AU - Monje, Michelle

PY - 2015/6/9

Y1 - 2015/6/9

N2 - Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor panobinostat demonstrated therapeutic efficacy both in vitro and in DIPG orthotopic xenograft models. Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the two had synergistic effects. Together, these data suggest a promising therapeutic strategy for DIPG.

AB - Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor panobinostat demonstrated therapeutic efficacy both in vitro and in DIPG orthotopic xenograft models. Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the two had synergistic effects. Together, these data suggest a promising therapeutic strategy for DIPG.

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U2 - 10.1038/nm.3855

DO - 10.1038/nm.3855

M3 - Article

C2 - 25939062

AN - SCOPUS:84930764914

SN - 1078-8956

VL - 21

SP - 555

EP - 559

JO - Nature Medicine

JF - Nature Medicine

IS - 6

ER -