Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages

Elise Chapiro; Nathalie Leporrier; Isabelle Radford-Weiss; Christian Bastard; Hossein Mossafa; Dominique Leroux; Isabelle Tigaud; Marc De Braekeleer; Christine Terré; Françoise Brizard; Evelyne Callet-Bauchu; Stéphanie Struski; Lauren Veronese; Sandra Fert-Ferrer; Sylvie Taviaux; Claude Lesty; Frédéric Davi; Hélène Merle-Béral; Olivier A. Bernard; Laurent Sutton; Sophie D. Raynaud; Florence Nguyen-Khac

doi:10.1016/j.leukres.2009.03.042

Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages

Elise Chapiro, Nathalie Leporrier, Isabelle Radford-Weiss, Christian Bastard, Hossein Mossafa, Dominique Leroux, Isabelle Tigaud, Marc De Braekeleer, Christine Terré, Françoise Brizard, Evelyne Callet-Bauchu, Stéphanie Struski, Lauren Veronese, Sandra Fert-Ferrer, Sylvie Taviaux, Claude Lesty, Frédéric Davi, Hélène Merle-Béral, Olivier A. Bernard, Laurent SuttonSophie D. Raynaud, Florence Nguyen-Khac

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Résumé

Using array-based CGH, we identified 2p gain in 22/78 (28%) untreated Binet stages B/C CLL, which was the second most frequent copy number change after 13q deletion. It never occurred as a sole abnormality and was associated with other changes (6q deletion; 1p gain). The region of 2p gain frequently included two oncogenes, REL and MYCN. All patients with gain of REL were unmutated for IGHV (p = 0.03). Gain of MYCN was associated with increased mRNA expression (p = 0.005), suggesting a pathogenic role for MYCN. Gain of 2p appears to be a marker of progression and may contribute to the poor prognosis.

langue originale	Anglais
Pages (de - à)	63-68
Nombre de pages	6
journal	Leukemia Research
Volume	34
Numéro de publication	1
Les DOIs	https://doi.org/10.1016/j.leukres.2009.03.042
état	Publié - 1 janv. 2010

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10.1016/j.leukres.2009.03.042

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Chapiro, E., Leporrier, N., Radford-Weiss, I., Bastard, C., Mossafa, H., Leroux, D., Tigaud, I., De Braekeleer, M., Terré, C., Brizard, F., Callet-Bauchu, E., Struski, S., Veronese, L., Fert-Ferrer, S., Taviaux, S., Lesty, C., Davi, F., Merle-Béral, H., Bernard, O. A., ... Nguyen-Khac, F. (2010). Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages. Leukemia Research, 34(1), 63-68. https://doi.org/10.1016/j.leukres.2009.03.042

@article{c1763ab110504c97b4abc9a1c30712ce,

title = "Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages",

abstract = "Using array-based CGH, we identified 2p gain in 22/78 (28%) untreated Binet stages B/C CLL, which was the second most frequent copy number change after 13q deletion. It never occurred as a sole abnormality and was associated with other changes (6q deletion; 1p gain). The region of 2p gain frequently included two oncogenes, REL and MYCN. All patients with gain of REL were unmutated for IGHV (p = 0.03). Gain of MYCN was associated with increased mRNA expression (p = 0.005), suggesting a pathogenic role for MYCN. Gain of 2p appears to be a marker of progression and may contribute to the poor prognosis.",

keywords = "2p gain, CLL, MYCN, REL",

author = "Elise Chapiro and Nathalie Leporrier and Isabelle Radford-Weiss and Christian Bastard and Hossein Mossafa and Dominique Leroux and Isabelle Tigaud and {De Braekeleer}, Marc and Christine Terr{\'e} and Fran{\c c}oise Brizard and Evelyne Callet-Bauchu and St{\'e}phanie Struski and Lauren Veronese and Sandra Fert-Ferrer and Sylvie Taviaux and Claude Lesty and Fr{\'e}d{\'e}ric Davi and H{\'e}l{\`e}ne Merle-B{\'e}ral and Bernard, {Olivier A.} and Laurent Sutton and Raynaud, {Sophie D.} and Florence Nguyen-Khac",

note = "Funding Information: This work was partly supported by a Roche France grant. We thank L. Merlin and J. Ong for technical assistance, K. Maloum for his support, S. B{\'e}thery-Dostes for her help in improving the manuscript. ",

year = "2010",

month = jan,

day = "1",

doi = "10.1016/j.leukres.2009.03.042",

language = "English",

volume = "34",

pages = "63--68",

journal = "Leukemia Research",

issn = "0145-2126",

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Chapiro, E, Leporrier, N, Radford-Weiss, I, Bastard, C, Mossafa, H, Leroux, D, Tigaud, I, De Braekeleer, M, Terré, C, Brizard, F, Callet-Bauchu, E, Struski, S, Veronese, L, Fert-Ferrer, S, Taviaux, S, Lesty, C, Davi, F, Merle-Béral, H, Bernard, OA, Sutton, L, Raynaud, SD & Nguyen-Khac, F 2010, 'Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages', Leukemia Research, VOL. 34, Numéro 1, p. 63-68. https://doi.org/10.1016/j.leukres.2009.03.042

Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages. / Chapiro, Elise; Leporrier, Nathalie; Radford-Weiss, Isabelle et al.
Dans: Leukemia Research, Vol 34, Numéro 1, 01.01.2010, p. 63-68.

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

TY - JOUR

T1 - Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages

AU - Chapiro, Elise

AU - Leporrier, Nathalie

AU - Radford-Weiss, Isabelle

AU - Bastard, Christian

AU - Mossafa, Hossein

AU - Leroux, Dominique

AU - Tigaud, Isabelle

AU - De Braekeleer, Marc

AU - Terré, Christine

AU - Brizard, Françoise

AU - Callet-Bauchu, Evelyne

AU - Struski, Stéphanie

AU - Veronese, Lauren

AU - Fert-Ferrer, Sandra

AU - Taviaux, Sylvie

AU - Lesty, Claude

AU - Davi, Frédéric

AU - Merle-Béral, Hélène

AU - Bernard, Olivier A.

AU - Sutton, Laurent

AU - Raynaud, Sophie D.

AU - Nguyen-Khac, Florence

N1 - Funding Information: This work was partly supported by a Roche France grant. We thank L. Merlin and J. Ong for technical assistance, K. Maloum for his support, S. Béthery-Dostes for her help in improving the manuscript.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Using array-based CGH, we identified 2p gain in 22/78 (28%) untreated Binet stages B/C CLL, which was the second most frequent copy number change after 13q deletion. It never occurred as a sole abnormality and was associated with other changes (6q deletion; 1p gain). The region of 2p gain frequently included two oncogenes, REL and MYCN. All patients with gain of REL were unmutated for IGHV (p = 0.03). Gain of MYCN was associated with increased mRNA expression (p = 0.005), suggesting a pathogenic role for MYCN. Gain of 2p appears to be a marker of progression and may contribute to the poor prognosis.

AB - Using array-based CGH, we identified 2p gain in 22/78 (28%) untreated Binet stages B/C CLL, which was the second most frequent copy number change after 13q deletion. It never occurred as a sole abnormality and was associated with other changes (6q deletion; 1p gain). The region of 2p gain frequently included two oncogenes, REL and MYCN. All patients with gain of REL were unmutated for IGHV (p = 0.03). Gain of MYCN was associated with increased mRNA expression (p = 0.005), suggesting a pathogenic role for MYCN. Gain of 2p appears to be a marker of progression and may contribute to the poor prognosis.

KW - 2p gain

KW - CLL

KW - MYCN

KW - REL

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U2 - 10.1016/j.leukres.2009.03.042

DO - 10.1016/j.leukres.2009.03.042

M3 - Article

C2 - 19406473

AN - SCOPUS:73549103619

SN - 0145-2126

VL - 34

SP - 63

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JO - Leukemia Research

JF - Leukemia Research

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