Gene copy number variations in breast cancer of Sub-Saharan African women

Madani Ly; Alexander Valent; Gangaly Diallo; Frédérique Penault-Lorca; Klaus Dumke; Virginie Marty; Philippe Viehl; Vladimir Lazar; Bastien Job; Catherine Richon; Veronique Scott; Dapa Aly Diallo; Jean François Bernaudin; Fabrice Andre

doi:10.1016/j.breast.2012.07.010

Gene copy number variations in breast cancer of Sub-Saharan African women

Madani Ly, Alexander Valent, Gangaly Diallo, Frédérique Penault-Lorca, Klaus Dumke, Virginie Marty, Philippe Viehl, Vladimir Lazar, Bastien Job, Catherine Richon, Veronique Scott, Dapa Aly Diallo, Jean François Bernaudin, Fabrice Andre

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

8 Citations (Scopus)

Résumé

The goal of this study was CGH array profiling of breast cancer from Malian women in order to define differences with those from USA. CGH array was performed in 28 samples, 17 with a triple negative phenotype. The profiles were compared to those of 106 tumors from USA. 6 chromosomal regions (6p21, 9q34, 11q13, 12q24, 17q25 and 22q12.1-22q13.1) were identified with a significant higher rate of copy number alterations. These regions contain several genes of interest including BCR. FISH and IHC confirmed that BCR was amplified and overexpressed particularly in triple negative tumors. Finally, 5 regions presented a high level of amplification in two or more samples, including 2 regions located between 9p22.3-9p23 and 9p23-9p24.1. This study confirms that breast cancers from African women present biological differences with those from USA. Larger studies are needed to go further in the identification of therapeutic targets that would be specific to African women.

langue originale	Anglais
Pages (de - à)	295-300
Nombre de pages	6
journal	Breast
Volume	22
Numéro de publication	3
Les DOIs	https://doi.org/10.1016/j.breast.2012.07.010
état	Publié - 1 janv. 2013

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10.1016/j.breast.2012.07.010

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@article{a812dcfca9614ed8aa8b7dee08f921ed,

title = "Gene copy number variations in breast cancer of Sub-Saharan African women",

abstract = "The goal of this study was CGH array profiling of breast cancer from Malian women in order to define differences with those from USA. CGH array was performed in 28 samples, 17 with a triple negative phenotype. The profiles were compared to those of 106 tumors from USA. 6 chromosomal regions (6p21, 9q34, 11q13, 12q24, 17q25 and 22q12.1-22q13.1) were identified with a significant higher rate of copy number alterations. These regions contain several genes of interest including BCR. FISH and IHC confirmed that BCR was amplified and overexpressed particularly in triple negative tumors. Finally, 5 regions presented a high level of amplification in two or more samples, including 2 regions located between 9p22.3-9p23 and 9p23-9p24.1. This study confirms that breast cancers from African women present biological differences with those from USA. Larger studies are needed to go further in the identification of therapeutic targets that would be specific to African women.",

keywords = "African women, BCR, Breast cancer, CGH array, Chromosomes, Triple negative",

author = "Madani Ly and Alexander Valent and Gangaly Diallo and Fr{\'e}d{\'e}rique Penault-Lorca and Klaus Dumke and Virginie Marty and Philippe Viehl and Vladimir Lazar and Bastien Job and Catherine Richon and Veronique Scott and Diallo, {Dapa Aly} and Bernaudin, {Jean Fran{\c c}ois} and Fabrice Andre",

year = "2013",

month = jan,

day = "1",

doi = "10.1016/j.breast.2012.07.010",

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T1 - Gene copy number variations in breast cancer of Sub-Saharan African women

AU - Ly, Madani

AU - Valent, Alexander

AU - Diallo, Gangaly

AU - Penault-Lorca, Frédérique

AU - Dumke, Klaus

AU - Marty, Virginie

AU - Viehl, Philippe

AU - Lazar, Vladimir

AU - Job, Bastien

AU - Richon, Catherine

AU - Scott, Veronique

AU - Diallo, Dapa Aly

AU - Bernaudin, Jean François

AU - Andre, Fabrice

PY - 2013/1/1

Y1 - 2013/1/1

N2 - The goal of this study was CGH array profiling of breast cancer from Malian women in order to define differences with those from USA. CGH array was performed in 28 samples, 17 with a triple negative phenotype. The profiles were compared to those of 106 tumors from USA. 6 chromosomal regions (6p21, 9q34, 11q13, 12q24, 17q25 and 22q12.1-22q13.1) were identified with a significant higher rate of copy number alterations. These regions contain several genes of interest including BCR. FISH and IHC confirmed that BCR was amplified and overexpressed particularly in triple negative tumors. Finally, 5 regions presented a high level of amplification in two or more samples, including 2 regions located between 9p22.3-9p23 and 9p23-9p24.1. This study confirms that breast cancers from African women present biological differences with those from USA. Larger studies are needed to go further in the identification of therapeutic targets that would be specific to African women.

AB - The goal of this study was CGH array profiling of breast cancer from Malian women in order to define differences with those from USA. CGH array was performed in 28 samples, 17 with a triple negative phenotype. The profiles were compared to those of 106 tumors from USA. 6 chromosomal regions (6p21, 9q34, 11q13, 12q24, 17q25 and 22q12.1-22q13.1) were identified with a significant higher rate of copy number alterations. These regions contain several genes of interest including BCR. FISH and IHC confirmed that BCR was amplified and overexpressed particularly in triple negative tumors. Finally, 5 regions presented a high level of amplification in two or more samples, including 2 regions located between 9p22.3-9p23 and 9p23-9p24.1. This study confirms that breast cancers from African women present biological differences with those from USA. Larger studies are needed to go further in the identification of therapeutic targets that would be specific to African women.

KW - African women

KW - BCR

KW - Breast cancer

KW - CGH array

KW - Chromosomes

KW - Triple negative

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DO - 10.1016/j.breast.2012.07.010

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