Genetic association between a 'standing' variant of NOD2 and bipolar disorder

José Oliveira; Nora Hamdani; Bruno Etain; Meriem Bennabi; Wahid Boukouaci; Kahina Amokrane; Catherine Fortier; François Marzais; Djaouida Bengoufa; Frank Bellivier; Chantal Henry; Jean Pierre Kahn; Dominique Charron; Rajagopal Krishnamoorthy; Marion Leboyer; Ryad Tamouza

doi:10.1016/j.imbio.2014.06.003

Genetic association between a 'standing' variant of NOD2 and bipolar disorder

José Oliveira, Nora Hamdani, Bruno Etain, Meriem Bennabi, Wahid Boukouaci, Kahina Amokrane, Catherine Fortier, François Marzais, Djaouida Bengoufa, Frank Bellivier, Chantal Henry, Jean Pierre Kahn, Dominique Charron, Rajagopal Krishnamoorthy, Marion Leboyer, Ryad Tamouza

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

15 Citations (Scopus)

Résumé

Bipolar disorders (BD) are chronic, multisystem and multifactorial disorders with significant lifetime morbidity, mortality and socio-economic burden. Understanding the underlying genetic and disease triggering environmental factors should improve diagnosis, prognosis, prevention and therapeutic management of the disease. Since intestinal innate dysimmunity seems to play a significant role in the etiopathogeny of BD, we explored in a sample of French Caucasian BD patients, the genetic polymorphisms of NOD2 (nucleotide-binding oligomerization domain containing 2) gene, a key player in such immunity. We found a Caucasian-specific 'standing' variation to be associated with BD. The significance of this finding is discussed in the context of Crohn's disease as well as the complex function of NOD2 in innate immunity.

langue originale	Anglais
Pages (de - à)	766-771
Nombre de pages	6
journal	Immunobiology
Volume	219
Numéro de publication	10
Les DOIs	https://doi.org/10.1016/j.imbio.2014.06.003
état	Publié - 1 janv. 2014
Modification externe	Oui

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10.1016/j.imbio.2014.06.003

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Oliveira, J., Hamdani, N., Etain, B., Bennabi, M., Boukouaci, W., Amokrane, K., Fortier, C., Marzais, F., Bengoufa, D., Bellivier, F., Henry, C., Kahn, J. P., Charron, D., Krishnamoorthy, R., Leboyer, M., & Tamouza, R. (2014). Genetic association between a 'standing' variant of NOD2 and bipolar disorder. Immunobiology, 219(10), 766-771. https://doi.org/10.1016/j.imbio.2014.06.003

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abstract = "Bipolar disorders (BD) are chronic, multisystem and multifactorial disorders with significant lifetime morbidity, mortality and socio-economic burden. Understanding the underlying genetic and disease triggering environmental factors should improve diagnosis, prognosis, prevention and therapeutic management of the disease. Since intestinal innate dysimmunity seems to play a significant role in the etiopathogeny of BD, we explored in a sample of French Caucasian BD patients, the genetic polymorphisms of NOD2 (nucleotide-binding oligomerization domain containing 2) gene, a key player in such immunity. We found a Caucasian-specific 'standing' variation to be associated with BD. The significance of this finding is discussed in the context of Crohn's disease as well as the complex function of NOD2 in innate immunity.",

keywords = "Bipolar disorder, Immunogenetics, Inflammation, Innate immunity, NOD2",

author = "Jos{\'e} Oliveira and Nora Hamdani and Bruno Etain and Meriem Bennabi and Wahid Boukouaci and Kahina Amokrane and Catherine Fortier and Fran{\c c}ois Marzais and Djaouida Bengoufa and Frank Bellivier and Chantal Henry and Kahn, {Jean Pierre} and Dominique Charron and Rajagopal Krishnamoorthy and Marion Leboyer and Ryad Tamouza",

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Oliveira, J, Hamdani, N, Etain, B, Bennabi, M, Boukouaci, W, Amokrane, K, Fortier, C, Marzais, F, Bengoufa, D, Bellivier, F, Henry, C, Kahn, JP, Charron, D, Krishnamoorthy, R, Leboyer, M & Tamouza, R 2014, 'Genetic association between a 'standing' variant of NOD2 and bipolar disorder', Immunobiology, VOL. 219, Numéro 10, p. 766-771. https://doi.org/10.1016/j.imbio.2014.06.003

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T1 - Genetic association between a 'standing' variant of NOD2 and bipolar disorder

AU - Oliveira, José

AU - Hamdani, Nora

AU - Etain, Bruno

AU - Bennabi, Meriem

AU - Boukouaci, Wahid

AU - Amokrane, Kahina

AU - Fortier, Catherine

AU - Marzais, François

AU - Bengoufa, Djaouida

AU - Bellivier, Frank

AU - Henry, Chantal

AU - Kahn, Jean Pierre

AU - Charron, Dominique

AU - Krishnamoorthy, Rajagopal

AU - Leboyer, Marion

AU - Tamouza, Ryad

PY - 2014/1/1

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AB - Bipolar disorders (BD) are chronic, multisystem and multifactorial disorders with significant lifetime morbidity, mortality and socio-economic burden. Understanding the underlying genetic and disease triggering environmental factors should improve diagnosis, prognosis, prevention and therapeutic management of the disease. Since intestinal innate dysimmunity seems to play a significant role in the etiopathogeny of BD, we explored in a sample of French Caucasian BD patients, the genetic polymorphisms of NOD2 (nucleotide-binding oligomerization domain containing 2) gene, a key player in such immunity. We found a Caucasian-specific 'standing' variation to be associated with BD. The significance of this finding is discussed in the context of Crohn's disease as well as the complex function of NOD2 in innate immunity.

KW - Bipolar disorder

KW - Immunogenetics

KW - Inflammation

KW - Innate immunity

KW - NOD2

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