Résumé
Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.
langue originale | Anglais |
---|---|
Numéro d'article | 7138 |
journal | Nature Communications |
Volume | 6 |
Les DOIs | |
état | Publié - 7 juil. 2015 |
Modification externe | Oui |
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Dans: Nature Communications, Vol 6, 7138, 07.07.2015.
Résultats de recherche: Contribution à un journal › Article › Revue par des pairs
TY - JOUR
T1 - Genome-wide association study of colorectal cancer identifies six new susceptibility loci
AU - Schumacher, Fredrick R.
AU - Schmit, Stephanie L.
AU - Jiao, Shuo
AU - Edlund, Christopher K.
AU - Wang, Hansong
AU - Zhang, Ben
AU - Hsu, Li
AU - Huang, Shu Chen
AU - Fischer, Christopher P.
AU - Harju, John F.
AU - Idos, Gregory E.
AU - Lejbkowicz, Flavio
AU - Manion, Frank J.
AU - McDonnell, Kevin
AU - McNeil, Caroline E.
AU - Melas, Marilena
AU - Rennert, Hedy S.
AU - Shi, Wei
AU - Thomas, Duncan C.
AU - Van Den Berg, David J.
AU - Hutter, Carolyn M.
AU - Aragaki, Aaron K.
AU - Butterbach, Katja
AU - Caan, Bette J.
AU - Carlson, Christopher S.
AU - Chanock, Stephen J.
AU - Curtis, Keith R.
AU - Fuchs, Charles S.
AU - Gala, Manish
AU - Giocannucci, Edward L.
AU - Gogarten, Stephanie M.
AU - Hayes, Richard B.
AU - Henderson, Brian
AU - Hunter, David J.
AU - Jackson, Rebecca D.
AU - Kolonel, Laurence N.
AU - Kooperberg, Charles
AU - Kury, Sebastian
AU - Lacroix, Andrea
AU - Laurie, Cathy C.
AU - Laurie, Cecelia A.
AU - Lemire, Mathiew
AU - Levine, David
AU - Ma, Jing
AU - Makar, Karen W.
AU - Qu, Conghui
AU - Taverna, Darin
AU - Ulrich, Cornelia M.
AU - Wu, Kana
AU - Kono, Suminori
AU - West, Dee W.
AU - Berndt, Sonja I.
AU - Bezieau, Stephane
AU - Brenner, Hermann
AU - Campbell, Peter T.
AU - Chan, Andrew T.
AU - Chang-Claude, Jenny
AU - Coetzee, Gerhard A.
AU - Conti, David V.
AU - Duggan, David
AU - Figueiredo, Jane C.
AU - Fortini, Barbara K.
AU - Gallinger, Steven J.
AU - Gauderman, W. James
AU - Giles, Graham
AU - Green, Roger
AU - Haile, Robert
AU - Harrison, Tabitha A.
AU - Hoffmeister, Michael
AU - Hopper, John L.
AU - Hudson, Thomas J.
AU - Jacobs, Eric
AU - Iwasaki, Motoki
AU - Jee, Sun Ha
AU - Jenkins, Mark
AU - Jia, Wei Hua
AU - Joshi, Amit
AU - Li, Li
AU - Lindor, Noralene M.
AU - Matsuo, Keitaro
AU - Moreno, Victor
AU - Mukherjee, Bhramar
AU - Newcomb, Polly A.
AU - Potter, John D.
AU - Raskin, Leon
AU - Rennert, Gad
AU - Rosse, Stephanie
AU - Severi, Gianluca
AU - Schoen, Robert E.
AU - Seminara, Daniela
AU - Shu, Xiao Ou
AU - Slattery, Martha L.
AU - Tsugane, Shoichiro
AU - White, Emily
AU - Xiang, Yong Bing
AU - Zanke, Brent W.
AU - Zheng, Wei
AU - Le Marchand, Loic
AU - Casey, Graham
AU - Gruber, Stephen B.
AU - Peters, Ulrike
N1 - Publisher Copyright: © 2015 Macmillan Publishers Limited.
PY - 2015/7/7
Y1 - 2015/7/7
N2 - Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.
AB - Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.
UR - http://www.scopus.com/inward/record.url?scp=84936745391&partnerID=8YFLogxK
U2 - 10.1038/ncomms8138
DO - 10.1038/ncomms8138
M3 - Article
C2 - 26151821
AN - SCOPUS:84936745391
SN - 2041-1723
VL - 6
JO - Nature Communications
JF - Nature Communications
M1 - 7138
ER -