Genomic grade adds prognostic value in invasive lobular carcinoma

O. Metzger-Filho; S. Michiels; F. Bertucci; A. Catteau; R. Salgado; C. Galant; D. Fumagalli; S. K. Singhal; C. Desmedt; M. Ignatiadis; S. Haussy; P. Finetti; D. Birnbaum; K. S. Saini; M. Berlière; I. Veys; E. de Azambuja; I. Bozovic; H. Peyro-Saint-Paul; D. Larsimont; M. Piccart; C. Sotiriou

doi:10.1093/annonc/mds280

Genomic grade adds prognostic value in invasive lobular carcinoma

O. Metzger-Filho, S. Michiels, F. Bertucci, A. Catteau, R. Salgado, C. Galant, D. Fumagalli, S. K. Singhal, C. Desmedt, M. Ignatiadis, S. Haussy, P. Finetti, D. Birnbaum, K. S. Saini, M. Berlière, I. Veys, E. de Azambuja, I. Bozovic, H. Peyro-Saint-Paul, D. LarsimontM. Piccart, C. Sotiriou

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

54 Citations (Scopus)

Résumé

Background: The prognostic value of histologic grade (HG) in invasive lobular carcinoma (ILC) remains uncertain, and most ILC tumors are graded as HG2. Genomic grade (GG) is a 97-gene signature that improves the prognostic value of HG. This study evaluates whether GG may overcome the limitations of HG in ILC. Methods: Gene expression data were generated from frozen tumor samples, and GG calculated according to the expression of 97 genes. The prognostic value of GG was assessed in a stratified Cox regression model for invasive disease-free survival (IDFS) and overall survival (OS). Results: A total of 166 patients were classified by GG. HG classified 33 (20%) tumors as HG1, 120 (73%) as HG2 and 12 (7%) as HG3. GG classified 106 (64%) tumors as GG low (GG1), 29 (17%) as GG high (GG3) and 31 (19%) as equivocal (cases not classified as GG1 or GG3). The median follow-up time was 6.5 years. In multivariate analyses, GG was associated with IDFS [HRGG3 vs GG1 5.6 (2.1-15.3); P < 0.001] and OS [HRGG3 vs GG1 7.2, 95% CI (1.6-32.2); P = 0.01]. Conclusions: GG outperformed HG in ILC and added prognostic value to classic clinicopathologic variables, including nodal status.

langue originale	Anglais
Pages (de - à)	377-384
Nombre de pages	8
journal	Annals of Oncology
Volume	24
Numéro de publication	2
Les DOIs	https://doi.org/10.1093/annonc/mds280
état	Publié - 1 janv. 2013
Modification externe	Oui

Accès au document

10.1093/annonc/mds280

Autres fichiers et liens

Lien vers la publication dans Scopus

Contient cette citation

Metzger-Filho, O., Michiels, S., Bertucci, F., Catteau, A., Salgado, R., Galant, C., Fumagalli, D., Singhal, S. K., Desmedt, C., Ignatiadis, M., Haussy, S., Finetti, P., Birnbaum, D., Saini, K. S., Berlière, M., Veys, I., de Azambuja, E., Bozovic, I., Peyro-Saint-Paul, H., ... Sotiriou, C. (2013). Genomic grade adds prognostic value in invasive lobular carcinoma. Annals of Oncology, 24(2), 377-384. https://doi.org/10.1093/annonc/mds280

@article{286022470e574d668ebbe48a67231f9b,

title = "Genomic grade adds prognostic value in invasive lobular carcinoma",

abstract = "Background: The prognostic value of histologic grade (HG) in invasive lobular carcinoma (ILC) remains uncertain, and most ILC tumors are graded as HG2. Genomic grade (GG) is a 97-gene signature that improves the prognostic value of HG. This study evaluates whether GG may overcome the limitations of HG in ILC. Methods: Gene expression data were generated from frozen tumor samples, and GG calculated according to the expression of 97 genes. The prognostic value of GG was assessed in a stratified Cox regression model for invasive disease-free survival (IDFS) and overall survival (OS). Results: A total of 166 patients were classified by GG. HG classified 33 (20%) tumors as HG1, 120 (73%) as HG2 and 12 (7%) as HG3. GG classified 106 (64%) tumors as GG low (GG1), 29 (17%) as GG high (GG3) and 31 (19%) as equivocal (cases not classified as GG1 or GG3). The median follow-up time was 6.5 years. In multivariate analyses, GG was associated with IDFS [HRGG3 vs GG1 5.6 (2.1-15.3); P < 0.001] and OS [HRGG3 vs GG1 7.2, 95% CI (1.6-32.2); P = 0.01]. Conclusions: GG outperformed HG in ILC and added prognostic value to classic clinicopathologic variables, including nodal status.",

keywords = "Breast cancer, Genomics, Lobular carcinoma, Prognosis",

author = "O. Metzger-Filho and S. Michiels and F. Bertucci and A. Catteau and R. Salgado and C. Galant and D. Fumagalli and Singhal, {S. K.} and C. Desmedt and M. Ignatiadis and S. Haussy and P. Finetti and D. Birnbaum and Saini, {K. S.} and M. Berli{\`e}re and I. Veys and {de Azambuja}, E. and I. Bozovic and H. Peyro-Saint-Paul and D. Larsimont and M. Piccart and C. Sotiriou",

year = "2013",

month = jan,

day = "1",

doi = "10.1093/annonc/mds280",

language = "English",

volume = "24",

pages = "377--384",

journal = "Annals of Oncology",

issn = "0923-7534",

number = "2",

}

Metzger-Filho, O, Michiels, S, Bertucci, F, Catteau, A, Salgado, R, Galant, C, Fumagalli, D, Singhal, SK, Desmedt, C, Ignatiadis, M, Haussy, S, Finetti, P, Birnbaum, D, Saini, KS, Berlière, M, Veys, I, de Azambuja, E, Bozovic, I, Peyro-Saint-Paul, H, Larsimont, D, Piccart, M & Sotiriou, C 2013, 'Genomic grade adds prognostic value in invasive lobular carcinoma', Annals of Oncology, VOL. 24, Numéro 2, p. 377-384. https://doi.org/10.1093/annonc/mds280

TY - JOUR

T1 - Genomic grade adds prognostic value in invasive lobular carcinoma

AU - Metzger-Filho, O.

AU - Michiels, S.

AU - Bertucci, F.

AU - Catteau, A.

AU - Salgado, R.

AU - Galant, C.

AU - Fumagalli, D.

AU - Singhal, S. K.

AU - Desmedt, C.

AU - Ignatiadis, M.

AU - Haussy, S.

AU - Finetti, P.

AU - Birnbaum, D.

AU - Saini, K. S.

AU - Berlière, M.

AU - Veys, I.

AU - de Azambuja, E.

AU - Bozovic, I.

AU - Peyro-Saint-Paul, H.

AU - Larsimont, D.

AU - Piccart, M.

AU - Sotiriou, C.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Background: The prognostic value of histologic grade (HG) in invasive lobular carcinoma (ILC) remains uncertain, and most ILC tumors are graded as HG2. Genomic grade (GG) is a 97-gene signature that improves the prognostic value of HG. This study evaluates whether GG may overcome the limitations of HG in ILC. Methods: Gene expression data were generated from frozen tumor samples, and GG calculated according to the expression of 97 genes. The prognostic value of GG was assessed in a stratified Cox regression model for invasive disease-free survival (IDFS) and overall survival (OS). Results: A total of 166 patients were classified by GG. HG classified 33 (20%) tumors as HG1, 120 (73%) as HG2 and 12 (7%) as HG3. GG classified 106 (64%) tumors as GG low (GG1), 29 (17%) as GG high (GG3) and 31 (19%) as equivocal (cases not classified as GG1 or GG3). The median follow-up time was 6.5 years. In multivariate analyses, GG was associated with IDFS [HRGG3 vs GG1 5.6 (2.1-15.3); P < 0.001] and OS [HRGG3 vs GG1 7.2, 95% CI (1.6-32.2); P = 0.01]. Conclusions: GG outperformed HG in ILC and added prognostic value to classic clinicopathologic variables, including nodal status.

AB - Background: The prognostic value of histologic grade (HG) in invasive lobular carcinoma (ILC) remains uncertain, and most ILC tumors are graded as HG2. Genomic grade (GG) is a 97-gene signature that improves the prognostic value of HG. This study evaluates whether GG may overcome the limitations of HG in ILC. Methods: Gene expression data were generated from frozen tumor samples, and GG calculated according to the expression of 97 genes. The prognostic value of GG was assessed in a stratified Cox regression model for invasive disease-free survival (IDFS) and overall survival (OS). Results: A total of 166 patients were classified by GG. HG classified 33 (20%) tumors as HG1, 120 (73%) as HG2 and 12 (7%) as HG3. GG classified 106 (64%) tumors as GG low (GG1), 29 (17%) as GG high (GG3) and 31 (19%) as equivocal (cases not classified as GG1 or GG3). The median follow-up time was 6.5 years. In multivariate analyses, GG was associated with IDFS [HRGG3 vs GG1 5.6 (2.1-15.3); P < 0.001] and OS [HRGG3 vs GG1 7.2, 95% CI (1.6-32.2); P = 0.01]. Conclusions: GG outperformed HG in ILC and added prognostic value to classic clinicopathologic variables, including nodal status.

KW - Breast cancer

KW - Genomics

KW - Lobular carcinoma

KW - Prognosis

UR - http://www.scopus.com/inward/record.url?scp=84873826191&partnerID=8YFLogxK

U2 - 10.1093/annonc/mds280

DO - 10.1093/annonc/mds280

M3 - Article

C2 - 23028037

AN - SCOPUS:84873826191

SN - 0923-7534

VL - 24

SP - 377

EP - 384

JO - Annals of Oncology

JF - Annals of Oncology

IS - 2

ER -