TY - JOUR
T1 - Genomics and Epigenomics in the Molecular Biology of Melanoma—A Prerequisite for Biomarkers Studies
AU - Zob, Daniela Luminita
AU - Augustin, Iolanda
AU - Caba, Lavinia
AU - Panzaru, Monica Cristina
AU - Popa, Setalia
AU - Popa, Alina Delia
AU - Florea, Laura
AU - Gorduza, Eusebiu Vlad
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - Melanoma is a common and aggressive tumor originating from melanocytes. The increasing incidence of cutaneous melanoma in recent last decades highlights the need for predictive biomarkers studies. Melanoma development is a complex process, involving the interplay of genetic, epigenetic, and environmental factors. Genetic aberrations include BRAF, NRAS, NF1, MAP2K1/MAP2K2, KIT, GNAQ, GNA11, CDKN2A, TERT mutations, and translocations of kinases. Epigenetic alterations involve microRNAs, non-coding RNAs, histones modifications, and abnormal DNA methylations. Genetic aberrations and epigenetic marks are important as biomarkers for the diagnosis, prognosis, and prediction of disease recurrence, and for therapeutic targets. This review summarizes our current knowledge of the genomic and epigenetic changes in melanoma and discusses the latest scientific information.
AB - Melanoma is a common and aggressive tumor originating from melanocytes. The increasing incidence of cutaneous melanoma in recent last decades highlights the need for predictive biomarkers studies. Melanoma development is a complex process, involving the interplay of genetic, epigenetic, and environmental factors. Genetic aberrations include BRAF, NRAS, NF1, MAP2K1/MAP2K2, KIT, GNAQ, GNA11, CDKN2A, TERT mutations, and translocations of kinases. Epigenetic alterations involve microRNAs, non-coding RNAs, histones modifications, and abnormal DNA methylations. Genetic aberrations and epigenetic marks are important as biomarkers for the diagnosis, prognosis, and prediction of disease recurrence, and for therapeutic targets. This review summarizes our current knowledge of the genomic and epigenetic changes in melanoma and discusses the latest scientific information.
KW - biomarkers
KW - cutaneous melanoma
KW - epigenomics
KW - genomics
UR - http://www.scopus.com/inward/record.url?scp=85145901888&partnerID=8YFLogxK
U2 - 10.3390/ijms24010716
DO - 10.3390/ijms24010716
M3 - Review article
C2 - 36614156
AN - SCOPUS:85145901888
SN - 1661-6596
VL - 24
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 1
M1 - 716
ER -