Gold nanoparticles conjugated with cisplatin/doxorubicin/capecitabine lower the chemoresistance of hepatocellular carcinoma-derived cancer cells

Ciprian Tomuleasa, Olga Soritau, Anamaria Orza, Mircea Dudea, Bobe Petrushev, Ofelia Mosteanu, Sergiu Susman, Adrian Florea, Emoke Pall, Mihaela Aldea, Gabriel Kacso, Victor Cristea, Ioana Berindan-Neagoe, Alexandru Irimie

Résultats de recherche: Contribution à un journalArticleRevue par des pairs

119 Citations (Scopus)

Résumé

Background & Aims: The aim of the current study was to evaluate in vitro the anti-tumor efficacy of gold nanoparticles (GNPs) conjugated with conventional chemotherapy drugs for the treatment of liver cancer. This approach based on gold proposes a novel platform therapy with minimal toxicity and increased efficacy profiles for the destruction of hepatic cancer cells. methods. GNPs, stabilized with a monolayer of L-aspartate and additional cytostatic drugs, were successfully used as a complex tumor-targeting drug-delivery system. The drugs (doxorubicin, cisplatin, and capecitabine) were non-covalently conjugated onto the hydrophilic assemblies of GNPs-L-Aspartate nanostructure. Transmission electron microscopy was used to characterize the morphological and structural properties of these drug-metallic nanostructures. Results. The cellular proliferation rates in the presence of the anti-cancer drugs delivered by the GNPs were found to be statistically lower than those of cells exposed to the cytostatic drugs alone, indicating that GNPs facilitated an increased susceptibility of cancer cells to cisplatin, doxorubicin, and capecitabine plus ribavirin. Conclusion. This approach could offer a new chemotherapy strategy for patients diagnosed with unresectable hepatocellular carcinoma (HCC).

langue originaleAnglais
Pages (de - à)188-196
Nombre de pages9
journalJournal of Gastrointestinal and Liver Diseases
Volume21
Numéro de publication2
étatPublié - 1 juin 2012
Modification externeOui

Contient cette citation