@article{c115b9d49ea941529109c9e11a2737c3,
title = "Heating it up: Oncolytic viruses make tumors {\textquoteleft}hot{\textquoteright} and suitable for checkpoint blockade immunotherapies",
abstract = "Immune checkpoint blockade is less efficient in patients bearing immunologically {\textquoteleft}cold{\textquoteright} tumors. Oncolytic viruses, which were originally discovered for their ability to preferentially kill malignant cells, can recondition the tumor microenvironment. Supporting this hypothesis, two new studies published in Science Translational Medicine show that adjuvant-like activities of oncolytic viruses make brain and breast tumors {\textquoteleft}hot{\textquoteright} and sensitize them for subsequent immune checkpoint blockade.",
keywords = "CTLA-4, Immunosurveillance, Inflammation and cancer, PD-1, PD-L1, antibodies, antitumor response, antiviral response, immune checkpoint, immunosurveillance, immunotherapy, models of immunostimulation, oncolytic virus, therapeutic antibodies",
author = "Shashi Gujar and Pol, {Jonathan G.} and Guido Kroemer",
note = "Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 The Author(s). Published with license by Taylor & Francis Group, LLC. {\textcopyright} 2018, {\textcopyright} Shashi Gujar, Jonathan G. Pol and Guido Kroemer.",
year = "2018",
month = aug,
day = "3",
doi = "10.1080/2162402X.2018.1442169",
language = "English",
volume = "7",
journal = "OncoImmunology",
issn = "2162-4011",
number = "8",
}