Heterogeneous intratumor irradiation: a new partner for immunotherapy

Paul Bergeron, Fabien Milliat, Eric Deutsch, Michele Mondini

    Résultats de recherche: Contribution à un journalLetterRevue par des pairs

    1 Citation (Scopus)

    Résumé

    We recently demonstrated that a heterogeneous tumor irradiation strategy, combining high-dose and low-dose radiotherapy (RT) within the same tumor volume, can synergize with immunotherapy in mice. Our findings indicate that heterogeneous RT doses may promote the spatial diversification of the antitumor immune response. Spatial fractionation of the RT dose has the potential to enhance the therapeutic index of RT/IO combinations, particularly in scenarios where irradiating the entire tumor volume is unfeasible or excessively harmful to the patient.

    langue originaleAnglais
    Numéro d'article2434280
    journalOncoImmunology
    Volume13
    Numéro de publication1
    Les DOIs
    étatPublié - 1 janv. 2024

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