High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia

S. P. Romana; H. Poirel; M. Leconiat; M. A. Flexor; M. Mauchauffé; P. Jonveaux; E. A. Macintyre; R. Berger; O. A. Bernard

doi:10.1182/blood.v86.11.4263.bloodjournal86114263

High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia

S. P. Romana, H. Poirel, M. Leconiat, M. A. Flexor, M. Mauchauffé, P. Jonveaux, E. A. Macintyre, R. Berger, O. A. Bernard

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Résumé

The recurrent t(12;21)(p12;q22) translocation fuses two genes, TEL and AML1, that have previously been shown to be independently involved in myeloid malignant proliferations. A search for rearrangement of the TEL locus in the region known to be involved in t(12;21) was performed by Southern blotting in a panel of hematopoietic malignancies. The presence of a t(12;21) was confirmed by fluorescence in situ hybridization (FISH) and/or reverse transcriptase (RT)-polymerase chain reaction (PCR). We report that fusion of TEL to AML1 is specifically observed in at least 16% of the childhood B- lineage acute lymphoblastic leukemia (ALL) investigated, none of which had been previously identified as harboring t(12;21).

langue originale	Anglais
Pages (de - à)	4263-4269
Nombre de pages	7
journal	Blood
Volume	86
Numéro de publication	11
Les DOIs	https://doi.org/10.1182/blood.v86.11.4263.bloodjournal86114263
état	Publié - 1 déc. 1995

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10.1182/blood.v86.11.4263.bloodjournal86114263

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title = "High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia",

abstract = "The recurrent t(12;21)(p12;q22) translocation fuses two genes, TEL and AML1, that have previously been shown to be independently involved in myeloid malignant proliferations. A search for rearrangement of the TEL locus in the region known to be involved in t(12;21) was performed by Southern blotting in a panel of hematopoietic malignancies. The presence of a t(12;21) was confirmed by fluorescence in situ hybridization (FISH) and/or reverse transcriptase (RT)-polymerase chain reaction (PCR). We report that fusion of TEL to AML1 is specifically observed in at least 16% of the childhood B- lineage acute lymphoblastic leukemia (ALL) investigated, none of which had been previously identified as harboring t(12;21).",

author = "Romana, {S. P.} and H. Poirel and M. Leconiat and Flexor, {M. A.} and M. Mauchauff{\'e} and P. Jonveaux and Macintyre, {E. A.} and R. Berger and Bernard, {O. A.}",

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T1 - High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia

AU - Romana, S. P.

AU - Poirel, H.

AU - Leconiat, M.

AU - Flexor, M. A.

AU - Mauchauffé, M.

AU - Jonveaux, P.

AU - Macintyre, E. A.

AU - Berger, R.

AU - Bernard, O. A.

PY - 1995/12/1

Y1 - 1995/12/1

N2 - The recurrent t(12;21)(p12;q22) translocation fuses two genes, TEL and AML1, that have previously been shown to be independently involved in myeloid malignant proliferations. A search for rearrangement of the TEL locus in the region known to be involved in t(12;21) was performed by Southern blotting in a panel of hematopoietic malignancies. The presence of a t(12;21) was confirmed by fluorescence in situ hybridization (FISH) and/or reverse transcriptase (RT)-polymerase chain reaction (PCR). We report that fusion of TEL to AML1 is specifically observed in at least 16% of the childhood B- lineage acute lymphoblastic leukemia (ALL) investigated, none of which had been previously identified as harboring t(12;21).

AB - The recurrent t(12;21)(p12;q22) translocation fuses two genes, TEL and AML1, that have previously been shown to be independently involved in myeloid malignant proliferations. A search for rearrangement of the TEL locus in the region known to be involved in t(12;21) was performed by Southern blotting in a panel of hematopoietic malignancies. The presence of a t(12;21) was confirmed by fluorescence in situ hybridization (FISH) and/or reverse transcriptase (RT)-polymerase chain reaction (PCR). We report that fusion of TEL to AML1 is specifically observed in at least 16% of the childhood B- lineage acute lymphoblastic leukemia (ALL) investigated, none of which had been previously identified as harboring t(12;21).

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