TY - JOUR
T1 - High-grade glioma in children under 5 years of age
T2 - A chemotherapy only approach with the BBSFOP protocol
AU - Dufour, C.
AU - Grill, J.
AU - Lellouch-Tubiana, A.
AU - Puget, S.
AU - Chastagner, P.
AU - Frappaz, D.
AU - Doz, F.
AU - Pichon, F.
AU - Plantaz, D.
AU - Gentet, J. C.
AU - Raquin, M. A.
AU - Kalifa, C.
PY - 2006/11/1
Y1 - 2006/11/1
N2 - The aim of this study was to evaluate a chemotherapy strategy that avoids radiotherapy in first-line treatment of young children with high-grade glioma. A total of 21 children under 5 years of age received the BBSFOP protocol, comprising seven cycles of three drug pairs (carboplatin/procarbazine, cisplatin/etoposide and vincristine/cyclophosphamide) administered over a 16 month period. Radiotherapy was performed in case of recurrence/progression. Median age at diagnosis was 23 months. Histology was classified as World Health Organisation (WHO) grade III in 13 and grade IV in 8. Of the 13 children with a residual tumour, chemotherapy induced 2 partial responses (PR), 1 minor response (MR) and 1 stable disease (SD) with no recurrent disease. Five-year progression-free survival was 35% and 5-year overall survival was 59%, with a median follow-up of 5.2 years. At the last update, 12 children were alive (10 without radiotherapy). In conclusion, this study shows that an adjuvant chemotherapy first approach is safe and allows radiotherapy to be avoided in selected children.
AB - The aim of this study was to evaluate a chemotherapy strategy that avoids radiotherapy in first-line treatment of young children with high-grade glioma. A total of 21 children under 5 years of age received the BBSFOP protocol, comprising seven cycles of three drug pairs (carboplatin/procarbazine, cisplatin/etoposide and vincristine/cyclophosphamide) administered over a 16 month period. Radiotherapy was performed in case of recurrence/progression. Median age at diagnosis was 23 months. Histology was classified as World Health Organisation (WHO) grade III in 13 and grade IV in 8. Of the 13 children with a residual tumour, chemotherapy induced 2 partial responses (PR), 1 minor response (MR) and 1 stable disease (SD) with no recurrent disease. Five-year progression-free survival was 35% and 5-year overall survival was 59%, with a median follow-up of 5.2 years. At the last update, 12 children were alive (10 without radiotherapy). In conclusion, this study shows that an adjuvant chemotherapy first approach is safe and allows radiotherapy to be avoided in selected children.
KW - Astrocytoma
KW - Chemotherapy
KW - High-grade glioma
KW - Infants
KW - Oligodendroglioma
UR - http://www.scopus.com/inward/record.url?scp=33750516513&partnerID=8YFLogxK
U2 - 10.1016/j.ejca.2006.06.021
DO - 10.1016/j.ejca.2006.06.021
M3 - Article
C2 - 16962317
AN - SCOPUS:33750516513
SN - 0959-8049
VL - 42
SP - 2939
EP - 2945
JO - European Journal of Cancer
JF - European Journal of Cancer
IS - 17
ER -