Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation

David Castel; Thomas Kergrohen; Arnault Tauziède-Espariat; Alan Mackay; Samia Ghermaoui; Emmanuèle Lechapt; Stefan M. Pfister; Christof M. Kramm; Nathalie Boddaert; Thomas Blauwblomme; Stéphanie Puget; Kévin Beccaria; Chris Jones; David T.W. Jones; Pascale Varlet; Jacques Grill; Marie Anne Debily

doi:10.1007/s00401-020-02142-w

Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation

David Castel, Thomas Kergrohen, Arnault Tauziède-Espariat, Alan Mackay, Samia Ghermaoui, Emmanuèle Lechapt, Stefan M. Pfister, Christof M. Kramm, Nathalie Boddaert, Thomas Blauwblomme, Stéphanie Puget, Kévin Beccaria, Chris Jones, David T.W. Jones, Pascale Varlet, Jacques Grill, Marie Anne Debily

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

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langue originale	Anglais
Pages (de - à)	1109-1113
Nombre de pages	5
journal	Acta Neuropathologica
Volume	139
Numéro de publication	6
Les DOIs	https://doi.org/10.1007/s00401-020-02142-w
état	Publié - 1 juin 2020

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10.1007/s00401-020-02142-w

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Castel, D., Kergrohen, T., Tauziède-Espariat, A., Mackay, A., Ghermaoui, S., Lechapt, E., Pfister, S. M., Kramm, C. M., Boddaert, N., Blauwblomme, T., Puget, S., Beccaria, K., Jones, C., Jones, D. T. W., Varlet, P., Grill, J., & Debily, M. A. (2020). Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation. Acta Neuropathologica, 139(6), 1109-1113. https://doi.org/10.1007/s00401-020-02142-w

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title = "Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation",

author = "David Castel and Thomas Kergrohen and Arnault Tauzi{\`e}de-Espariat and Alan Mackay and Samia Ghermaoui and Emmanu{\`e}le Lechapt and Pfister, {Stefan M.} and Kramm, {Christof M.} and Nathalie Boddaert and Thomas Blauwblomme and St{\'e}phanie Puget and K{\'e}vin Beccaria and Chris Jones and Jones, {David T.W.} and Pascale Varlet and Jacques Grill and Debily, {Marie Anne}",

note = "Funding Information: DC, DTWJ, JG and MAD acknowledge KickCancer-ITCC (Innovative Therapies for Children with Cancer), Etoile de Martin (annual grant support to DC and RARE program with the Fondation Carrefour “Les Boucles du Coeur”) and Imagine for Margo for the financial support of this project, Necker Imagine Tumor and DNA biobank (BB-033-00065) for tumor and blood samples and centers participating in the BIOMEDE International Study and national PIs (Karsten Nysom, Klas Blomgren, Darren Hargrave, Dannis Van Vuurden, Francisco Bautista-Sirvent, Geoffrey McCowage). CJ and AM acknowledge NHS funding to the NIHR Biomedical Research Centre at the Royal Marsden and the ICR, and support from Abbie{\textquoteright}s Army and the CRIS Cancer Foundation. The INFORM personalised medicine study is supported by the Deutsche Krebshilfe, Deutsche Kinderkrebsstiftung, German Cancer Research Center (DKFZ), German Consortium for Translational Research (DKTK), the Shantella Stiftung, the “Ein Herz f{\"u}r Kinder” foundation and a donation from the Scheu family. Funding Information: DC, DTWJ, JG and MAD acknowledge KickCancer-ITCC?(Innovative Therapies for Children with Cancer), Etoile de Martin?(annual grant support to DC and RARE program with the Fondation Carrefour ?Les Boucles du Coeur?) and Imagine for Margo for the financial support of this project, Necker Imagine Tumor and DNA biobank (BB-033-00065) for tumor and blood samples and centers participating in the BIOMEDE International Study and national PIs (Karsten Nysom, Klas Blomgren, Darren Hargrave, Dannis Van Vuurden, Francisco Bautista-Sirvent, Geoffrey McCowage). CJ and AM acknowledge NHS funding to the NIHR Biomedical Research Centre at the Royal Marsden and the ICR, and support from Abbie?s Army and the CRIS Cancer Foundation. The INFORM personalised medicine study is supported by the Deutsche Krebshilfe, Deutsche Kinderkrebsstiftung, German Cancer Research Center (DKFZ), German Consortium for Translational Research (DKTK), the Shantella Stiftung, the ?Ein Herz f?r Kinder? foundation and a donation from the Scheu family.",

year = "2020",

month = jun,

day = "1",

doi = "10.1007/s00401-020-02142-w",

language = "English",

volume = "139",

pages = "1109--1113",

journal = "Acta Neuropathologica",

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Castel, D, Kergrohen, T, Tauziède-Espariat, A, Mackay, A, Ghermaoui, S, Lechapt, E, Pfister, SM, Kramm, CM, Boddaert, N, Blauwblomme, T, Puget, S, Beccaria, K, Jones, C, Jones, DTW, Varlet, P, Grill, J & Debily, MA 2020, 'Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation', Acta Neuropathologica, VOL. 139, Numéro 6, p. 1109-1113. https://doi.org/10.1007/s00401-020-02142-w

Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation. / Castel, David; Kergrohen, Thomas; Tauziède-Espariat, Arnault et al.
Dans: Acta Neuropathologica, Vol 139, Numéro 6, 01.06.2020, p. 1109-1113.

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

TY - JOUR

T1 - Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation

AU - Castel, David

AU - Kergrohen, Thomas

AU - Tauziède-Espariat, Arnault

AU - Mackay, Alan

AU - Ghermaoui, Samia

AU - Lechapt, Emmanuèle

AU - Pfister, Stefan M.

AU - Kramm, Christof M.

AU - Boddaert, Nathalie

AU - Blauwblomme, Thomas

AU - Puget, Stéphanie

AU - Beccaria, Kévin

AU - Jones, Chris

AU - Jones, David T.W.

AU - Varlet, Pascale

AU - Grill, Jacques

AU - Debily, Marie Anne

N1 - Funding Information: DC, DTWJ, JG and MAD acknowledge KickCancer-ITCC (Innovative Therapies for Children with Cancer), Etoile de Martin (annual grant support to DC and RARE program with the Fondation Carrefour “Les Boucles du Coeur”) and Imagine for Margo for the financial support of this project, Necker Imagine Tumor and DNA biobank (BB-033-00065) for tumor and blood samples and centers participating in the BIOMEDE International Study and national PIs (Karsten Nysom, Klas Blomgren, Darren Hargrave, Dannis Van Vuurden, Francisco Bautista-Sirvent, Geoffrey McCowage). CJ and AM acknowledge NHS funding to the NIHR Biomedical Research Centre at the Royal Marsden and the ICR, and support from Abbie’s Army and the CRIS Cancer Foundation. The INFORM personalised medicine study is supported by the Deutsche Krebshilfe, Deutsche Kinderkrebsstiftung, German Cancer Research Center (DKFZ), German Consortium for Translational Research (DKTK), the Shantella Stiftung, the “Ein Herz für Kinder” foundation and a donation from the Scheu family. Funding Information: DC, DTWJ, JG and MAD acknowledge KickCancer-ITCC?(Innovative Therapies for Children with Cancer), Etoile de Martin?(annual grant support to DC and RARE program with the Fondation Carrefour ?Les Boucles du Coeur?) and Imagine for Margo for the financial support of this project, Necker Imagine Tumor and DNA biobank (BB-033-00065) for tumor and blood samples and centers participating in the BIOMEDE International Study and national PIs (Karsten Nysom, Klas Blomgren, Darren Hargrave, Dannis Van Vuurden, Francisco Bautista-Sirvent, Geoffrey McCowage). CJ and AM acknowledge NHS funding to the NIHR Biomedical Research Centre at the Royal Marsden and the ICR, and support from Abbie?s Army and the CRIS Cancer Foundation. The INFORM personalised medicine study is supported by the Deutsche Krebshilfe, Deutsche Kinderkrebsstiftung, German Cancer Research Center (DKFZ), German Consortium for Translational Research (DKTK), the Shantella Stiftung, the ?Ein Herz f?r Kinder? foundation and a donation from the Scheu family.

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U2 - 10.1007/s00401-020-02142-w

DO - 10.1007/s00401-020-02142-w

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JO - Acta Neuropathologica

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