TY - JOUR
T1 - How Hematopoietic Stem Cells Respond to Irradiation
T2 - Similarities and Differences between Low and High Doses of Ionizing Radiations
AU - Henry, Elia
AU - Arcangeli, Marie Laure
N1 - Publisher Copyright:
© 2020 ISEH – Society for Hematology and Stem Cells
PY - 2021/2/1
Y1 - 2021/2/1
N2 - In this review, we will specifically address the newest insights on the effect of low doses of ionizing radiations on the hematopoietic stem cells, which are prone to long-term deleterious effects. Impact of high doses of irradiation on hematopoietic cells has been widely studied over the years, in line with the risk of accidental or terrorist exposure to irradiation and with a particular attention to the sensitivity of the hematopoietic system. Recently, more studies have focused on lower doses of irradiation on different tissues, due to the increasing exposure caused by medical imaging, radiotherapy or plane travelling for instance. Hence, we will delineate similarities and discrepancies in HSC response to high and low doses of irradiation from these studies.
AB - In this review, we will specifically address the newest insights on the effect of low doses of ionizing radiations on the hematopoietic stem cells, which are prone to long-term deleterious effects. Impact of high doses of irradiation on hematopoietic cells has been widely studied over the years, in line with the risk of accidental or terrorist exposure to irradiation and with a particular attention to the sensitivity of the hematopoietic system. Recently, more studies have focused on lower doses of irradiation on different tissues, due to the increasing exposure caused by medical imaging, radiotherapy or plane travelling for instance. Hence, we will delineate similarities and discrepancies in HSC response to high and low doses of irradiation from these studies.
UR - http://www.scopus.com/inward/record.url?scp=85099006090&partnerID=8YFLogxK
U2 - 10.1016/j.exphem.2020.12.001
DO - 10.1016/j.exphem.2020.12.001
M3 - Review article
C2 - 33290858
AN - SCOPUS:85099006090
SN - 0301-472X
VL - 94
SP - 11
EP - 19
JO - Experimental Hematology
JF - Experimental Hematology
ER -