How to improve the immunogenicity of chemotherapy and radiotherapy

Yuting Ma; Rosa Conforti; Laetitia Aymeric; Clara Locher; Oliver Kepp; Guido Kroemer; Laurence Zitvogel

doi:10.1007/s10555-011-9283-2

How to improve the immunogenicity of chemotherapy and radiotherapy

Yuting Ma, Rosa Conforti, Laetitia Aymeric, Clara Locher, Oliver Kepp, Guido Kroemer, Laurence Zitvogel

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

72 Citations (Scopus)

Résumé

Chemotherapy or radiotherapy could induce various tumor cell death modalities, releasing tumor-derived antigen as well as danger signals that could either be captured for triggering antitumor immune response or ignored. Exploring the interplay among therapeutic drugs, tumor cell death and the immune cells should improve diagnostic, prognostic, predictive, and therapeutic management of tumor. We summarized some of the cell death-derived danger signals and the mechanism for host to sense and response to cell death in the tumor microenvironment. Based on the recent clinical or experimental findings, several strategies have been suggested to improve the immunogenicity of cell death and augment antitumor immunity.

langue originale	Anglais
Pages (de - à)	71-82
Nombre de pages	12
journal	Cancer and Metastasis Reviews
Volume	30
Numéro de publication	1
Les DOIs	https://doi.org/10.1007/s10555-011-9283-2
état	Publié - 1 mars 2011

Accès au document

10.1007/s10555-011-9283-2

Autres fichiers et liens

Lien vers la publication dans Scopus

Contient cette citation

@article{471a2d3efb3c46bbb87ba76c3c56697e,

title = "How to improve the immunogenicity of chemotherapy and radiotherapy",

abstract = "Chemotherapy or radiotherapy could induce various tumor cell death modalities, releasing tumor-derived antigen as well as danger signals that could either be captured for triggering antitumor immune response or ignored. Exploring the interplay among therapeutic drugs, tumor cell death and the immune cells should improve diagnostic, prognostic, predictive, and therapeutic management of tumor. We summarized some of the cell death-derived danger signals and the mechanism for host to sense and response to cell death in the tumor microenvironment. Based on the recent clinical or experimental findings, several strategies have been suggested to improve the immunogenicity of cell death and augment antitumor immunity.",

keywords = "Cell death, DAMP, Immune cells, Tumor microenvironment",

author = "Yuting Ma and Rosa Conforti and Laetitia Aymeric and Clara Locher and Oliver Kepp and Guido Kroemer and Laurence Zitvogel",

note = "Funding Information: Acknowledgment The authors thank INFLA-CARE FP7 EU grant, INCa, Fondation pourla Recherche M{\'e}dicale, and Fondation de France. YM was supported by China Scholarship Council.",

year = "2011",

month = mar,

day = "1",

doi = "10.1007/s10555-011-9283-2",

language = "English",

volume = "30",

pages = "71--82",

journal = "Cancer and Metastasis Reviews",

issn = "0167-7659",

number = "1",

}

TY - JOUR

T1 - How to improve the immunogenicity of chemotherapy and radiotherapy

AU - Ma, Yuting

AU - Conforti, Rosa

AU - Aymeric, Laetitia

AU - Locher, Clara

AU - Kepp, Oliver

AU - Kroemer, Guido

AU - Zitvogel, Laurence

N1 - Funding Information: Acknowledgment The authors thank INFLA-CARE FP7 EU grant, INCa, Fondation pourla Recherche Médicale, and Fondation de France. YM was supported by China Scholarship Council.

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Chemotherapy or radiotherapy could induce various tumor cell death modalities, releasing tumor-derived antigen as well as danger signals that could either be captured for triggering antitumor immune response or ignored. Exploring the interplay among therapeutic drugs, tumor cell death and the immune cells should improve diagnostic, prognostic, predictive, and therapeutic management of tumor. We summarized some of the cell death-derived danger signals and the mechanism for host to sense and response to cell death in the tumor microenvironment. Based on the recent clinical or experimental findings, several strategies have been suggested to improve the immunogenicity of cell death and augment antitumor immunity.

AB - Chemotherapy or radiotherapy could induce various tumor cell death modalities, releasing tumor-derived antigen as well as danger signals that could either be captured for triggering antitumor immune response or ignored. Exploring the interplay among therapeutic drugs, tumor cell death and the immune cells should improve diagnostic, prognostic, predictive, and therapeutic management of tumor. We summarized some of the cell death-derived danger signals and the mechanism for host to sense and response to cell death in the tumor microenvironment. Based on the recent clinical or experimental findings, several strategies have been suggested to improve the immunogenicity of cell death and augment antitumor immunity.

KW - Cell death

KW - DAMP

KW - Immune cells

KW - Tumor microenvironment

UR - http://www.scopus.com/inward/record.url?scp=79952283465&partnerID=8YFLogxK

U2 - 10.1007/s10555-011-9283-2

DO - 10.1007/s10555-011-9283-2

M3 - Article

C2 - 21298323

AN - SCOPUS:79952283465

SN - 0167-7659

VL - 30

SP - 71

EP - 82

JO - Cancer and Metastasis Reviews

JF - Cancer and Metastasis Reviews

IS - 1

ER -