Résumé
Despite castrate levels of androgens, the androgen receptor (AR) remains active and continues to drive prostate cancer progression. Since the approval of docetaxel, four additional agents that show a survival benefit have been registered on the basis of randomized phase 3 trials. These have included enzalutamide and abiraterone, two agents designed specifically to affect the androgen axis, sipuleucel-T, which stimulates the immune system and cabazitaxel, a chemotherapeutic agent. Denosumab was shown to significantly delay skeletal-related events. Clinicians are challenged with a multitude of treatment options and potential sequencing of these agents that, consequently, make clinical decision making more complex. The induction of constitutively-active AR splice variants (AR-Vs) driving clonal proliferation of AR-negative and AR-independent metastases may be one major potential mechanism of resistance to new hormone therapies.
Titre traduit de la contribution | Prise en charge du cancer de prostate résistant à la castration métastatique |
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langue originale | Anglais |
Pages (de - à) | 509-515 |
Nombre de pages | 7 |
journal | Bulletin du Cancer |
Volume | 102 |
Numéro de publication | 6 |
Les DOIs | |
état | Publié - 1 juin 2015 |