HPV involvement in the tumor microenvironment and immune treatment in head and neck squamous cell carcinomas

Jérôme R. Lechien, Géraldine Descamps, Imelda Seminerio, Sonia Furgiuele, Didier Dequanter, Francois Mouawad, Cécile Badoual, Fabrice Journe, Sven Saussez

Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

51 Citations (Scopus)

Résumé

Head and neck squamous cell carcinomas (HNSCC) are one of the most prevalent cancers worldwide. Active human papillomavirus (HPV) infection has been identified as an important additional risk factor and seems to be associated with a better prognosis in non-drinker and non-smoker young patients with oropharyngeal SCC. The better response of the immune system against the HPV-induced HNSCC is suspected as a potential explanation for the better prognosis of young patients. To further assess this hypothesis, our review aims to shed light the current knowledge about the impact of HPV infection on the immune response in the context of HNSCC, focusing on the innate immune system, particularly highlighting the role of macrophages, Langerhans and myeloid cells, and on the adaptative immune system, pointing out the involvement of T regulatory, T CD8 and T CD4 lymphocytes. In addition, we also review the preventive (HPV vaccines) and therapeutic (checkpoint inhibitors) strategies against HPV-related HNSCC, stressing the use of anti- CTLA4, PD-L1, PD-L2 antibodies alone and in combination with other agents able to modulate immune responses.

langue originaleAnglais
Numéro d'article1060
journalCancers
Volume12
Numéro de publication5
Les DOIs
étatPublié - 1 mai 2020
Modification externeOui

Contient cette citation