Human immunodeficiency virus infection and AIDS in a person with negative serology

Luc Montagnier; Catherine Brenner; Sophie Chamaret; Denise Guétard; Alain Blanchard; Jacqueline Saint De Martin; Jean Dominique Poveda; Gilles Pialoux; Marie Lise Gougeon

doi:10.1086/513999

Human immunodeficiency virus infection and AIDS in a person with negative serology

Luc Montagnier, Catherine Brenner, Sophie Chamaret, Denise Guétard, Alain Blanchard, Jacqueline Saint De Martin, Jean Dominique Poveda, Gilles Pialoux, Marie Lise Gougeon

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Résumé

A 38-year-old woman resident of Ivory Coast died of AIDS, while remaining human immunodeficiency virus (HIV)-seronegative. She had been regularly tested because her husband was HIV-seropositive. The subject's lack of specific antibodies was assessed using commercial tests and confirmed by a radioimmunoprecipitation assay of the patient's virus. She was unquestionably HIV-1-infected, with a high plasma virus load, and her virus could be isolated. Molecular analyses indicated this retrovirus was clade A, which is common in Africa, and it was highly homologous to the virus isolated from her husband. The subject's seronegative status was thought to be due to rapid depletion of specific CD4⁺ helper T cells, resulting from accelerated disease progression, and was host-related rather than due to a specific HIV strain.

langue originale	Anglais
Pages (de - à)	955-959
Nombre de pages	5
journal	Journal of Infectious Diseases
Volume	175
Numéro de publication	4
Les DOIs	https://doi.org/10.1086/513999
état	Publié - 1 janv. 1997

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10.1086/513999

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title = "Human immunodeficiency virus infection and AIDS in a person with negative serology",

abstract = "A 38-year-old woman resident of Ivory Coast died of AIDS, while remaining human immunodeficiency virus (HIV)-seronegative. She had been regularly tested because her husband was HIV-seropositive. The subject's lack of specific antibodies was assessed using commercial tests and confirmed by a radioimmunoprecipitation assay of the patient's virus. She was unquestionably HIV-1-infected, with a high plasma virus load, and her virus could be isolated. Molecular analyses indicated this retrovirus was clade A, which is common in Africa, and it was highly homologous to the virus isolated from her husband. The subject's seronegative status was thought to be due to rapid depletion of specific CD4+ helper T cells, resulting from accelerated disease progression, and was host-related rather than due to a specific HIV strain.",

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AU - Montagnier, Luc

AU - Brenner, Catherine

AU - Chamaret, Sophie

AU - Guétard, Denise

AU - Blanchard, Alain

AU - De Martin, Jacqueline Saint

AU - Poveda, Jean Dominique

AU - Pialoux, Gilles

AU - Gougeon, Marie Lise

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