TY - JOUR
T1 - Human papilloma virus prevalence in HIV patients with head and neck squamous cell carcinoma
AU - Picard, Annabelle
AU - Badoual, Cécile
AU - Hourseau, Muriel
AU - Halimi, Caroline
AU - Pere, Hélène
AU - Dib, Fadia
AU - Barry, Béatrix
AU - Albert, Sébastien
N1 - Publisher Copyright:
© 2016 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2016/5/15
Y1 - 2016/5/15
N2 - Objective: The implication of human papilloma virus (HPV) in head and neck squamous cell carcinoma (HNSCC) is well established, especially in oropharyngeal SCC. HIV patients have a higher risk of persistent HPV infection. We investigated the role of HPV in HNSCC carcinogenesis in HIV population. Design: Retrospective monocentric study. Methods: We studied HIV patients who presented with HNSCC between 1994 and 2014. For each patient, tumor characteristics, HIV disease, and survival information were collected. Tumor HPV testing was performed using p16 immunohistochemistry (IHC), in-situ hybridization and PCR. We assessed the percentage of HPV in this population of HIV patients with HNSCC and compared HIV disease characteristics based on HPV status. Results: Forty-seven patients were included: 11 women/36 men, the median age was 50 years. Tumor HPV testing was performed in 40 patients. Tumors were located in oropharynx (32%), oral cavity (32%), larynx (21%), and hypopharynx (11%). At the time of diagnosis, median CD4+ level was 385cells/μl, 31% of the patients were stage (Centers for Disease Control, stage C). The percentage of HPV linked to HNSCC for all locations in HIV patients was 30% (n=12). HPV16 accounted for 50% of all HPV genotypes. HPV positive status was associated with a CD4+ nadir of less than 200 (P=0.026), but not with CD4+ level at time of diagnosis (P=0.414). HPV-negative tumors tend to be associated with poorer 5-year overall survival (hazard ratio=2.9, P=0.0711). Conclusion: HPV plays a critical role in HNSCC development in HIV population. HIV immunodeficiency may increase HPV persistence and progression of HNSCC.
AB - Objective: The implication of human papilloma virus (HPV) in head and neck squamous cell carcinoma (HNSCC) is well established, especially in oropharyngeal SCC. HIV patients have a higher risk of persistent HPV infection. We investigated the role of HPV in HNSCC carcinogenesis in HIV population. Design: Retrospective monocentric study. Methods: We studied HIV patients who presented with HNSCC between 1994 and 2014. For each patient, tumor characteristics, HIV disease, and survival information were collected. Tumor HPV testing was performed using p16 immunohistochemistry (IHC), in-situ hybridization and PCR. We assessed the percentage of HPV in this population of HIV patients with HNSCC and compared HIV disease characteristics based on HPV status. Results: Forty-seven patients were included: 11 women/36 men, the median age was 50 years. Tumor HPV testing was performed in 40 patients. Tumors were located in oropharynx (32%), oral cavity (32%), larynx (21%), and hypopharynx (11%). At the time of diagnosis, median CD4+ level was 385cells/μl, 31% of the patients were stage (Centers for Disease Control, stage C). The percentage of HPV linked to HNSCC for all locations in HIV patients was 30% (n=12). HPV16 accounted for 50% of all HPV genotypes. HPV positive status was associated with a CD4+ nadir of less than 200 (P=0.026), but not with CD4+ level at time of diagnosis (P=0.414). HPV-negative tumors tend to be associated with poorer 5-year overall survival (hazard ratio=2.9, P=0.0711). Conclusion: HPV plays a critical role in HNSCC development in HIV population. HIV immunodeficiency may increase HPV persistence and progression of HNSCC.
KW - head and neck squamous cell carcinoma
KW - HIV
KW - human papilloma virus
UR - http://www.scopus.com/inward/record.url?scp=84955558589&partnerID=8YFLogxK
U2 - 10.1097/QAD.0000000000001030
DO - 10.1097/QAD.0000000000001030
M3 - Article
C2 - 26807970
AN - SCOPUS:84955558589
SN - 0269-9370
VL - 30
SP - 1257
EP - 1266
JO - AIDS
JF - AIDS
IS - 8
ER -