Human papillomavirus prevalence and prognostic implication in oropharyngeal squamous cell carcinomas

Antoine E. Melkane; Anne Auperin; Patrick Saulnier; Ludovic Lacroix; Philippe Vielh; Odile Casiraghi; Issam Msakni; Françoise Drusch; Stéphane Temam

doi:10.1002/hed.23302

Human papillomavirus prevalence and prognostic implication in oropharyngeal squamous cell carcinomas

Antoine E. Melkane, Anne Auperin, Patrick Saulnier, Ludovic Lacroix, Philippe Vielh, Odile Casiraghi, Issam Msakni, Françoise Drusch, Stéphane Temam

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Résumé

Background Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) is associated with favorable survival. The purpose of this study was to evaluate the prevalence and prognostic significance of the HPV infection through both the p16 expression status and the oncogenic HPV DNA viral load. Methods A retrospective chart review was conducted on all patients treated for oropharyngeal SCC between January 2007 and June 2009. P16 expression status by immunohistochemistry and HPV DNA viral load by quantitative polymerase chain reaction (qPCR) were evaluated on routine pretreatment tumor samples. Results One hundred thirty-three patients (94 men and 39 women) were included in the study. Mean age was 59 years. One hundred twenty-two lesions (92%) were localized to lymphoid areas. Sixty-seven patients (50%) were p16+, and 87 patients (65%) harbored HPV DNA. The p16+/HPV DNA+ profile (48%) was associated with the most favorable prognosis. HPV16 was responsible for the majority of the infections (89%). Conclusion HPV is common among oropharyngeal SCC in France, and acts as an independent prognostic factor.

langue originale	Anglais
Pages (de - à)	257-265
Nombre de pages	9
journal	Head and Neck
Volume	36
Numéro de publication	2
Les DOIs	https://doi.org/10.1002/hed.23302
état	Publié - 1 févr. 2014

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10.1002/hed.23302

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title = "Human papillomavirus prevalence and prognostic implication in oropharyngeal squamous cell carcinomas",

abstract = "Background Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) is associated with favorable survival. The purpose of this study was to evaluate the prevalence and prognostic significance of the HPV infection through both the p16 expression status and the oncogenic HPV DNA viral load. Methods A retrospective chart review was conducted on all patients treated for oropharyngeal SCC between January 2007 and June 2009. P16 expression status by immunohistochemistry and HPV DNA viral load by quantitative polymerase chain reaction (qPCR) were evaluated on routine pretreatment tumor samples. Results One hundred thirty-three patients (94 men and 39 women) were included in the study. Mean age was 59 years. One hundred twenty-two lesions (92%) were localized to lymphoid areas. Sixty-seven patients (50%) were p16+, and 87 patients (65%) harbored HPV DNA. The p16+/HPV DNA+ profile (48%) was associated with the most favorable prognosis. HPV16 was responsible for the majority of the infections (89%). Conclusion HPV is common among oropharyngeal SCC in France, and acts as an independent prognostic factor.",

keywords = "human papillomavirus, oropharynx, p16, quantitative polymerase chain reaction, squamous cell carcinoma",

author = "Melkane, {Antoine E.} and Anne Auperin and Patrick Saulnier and Ludovic Lacroix and Philippe Vielh and Odile Casiraghi and Issam Msakni and Fran{\c c}oise Drusch and St{\'e}phane Temam",

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T1 - Human papillomavirus prevalence and prognostic implication in oropharyngeal squamous cell carcinomas

AU - Melkane, Antoine E.

AU - Auperin, Anne

AU - Saulnier, Patrick

AU - Lacroix, Ludovic

AU - Vielh, Philippe

AU - Casiraghi, Odile

AU - Msakni, Issam

AU - Drusch, Françoise

AU - Temam, Stéphane

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Background Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) is associated with favorable survival. The purpose of this study was to evaluate the prevalence and prognostic significance of the HPV infection through both the p16 expression status and the oncogenic HPV DNA viral load. Methods A retrospective chart review was conducted on all patients treated for oropharyngeal SCC between January 2007 and June 2009. P16 expression status by immunohistochemistry and HPV DNA viral load by quantitative polymerase chain reaction (qPCR) were evaluated on routine pretreatment tumor samples. Results One hundred thirty-three patients (94 men and 39 women) were included in the study. Mean age was 59 years. One hundred twenty-two lesions (92%) were localized to lymphoid areas. Sixty-seven patients (50%) were p16+, and 87 patients (65%) harbored HPV DNA. The p16+/HPV DNA+ profile (48%) was associated with the most favorable prognosis. HPV16 was responsible for the majority of the infections (89%). Conclusion HPV is common among oropharyngeal SCC in France, and acts as an independent prognostic factor.

AB - Background Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) is associated with favorable survival. The purpose of this study was to evaluate the prevalence and prognostic significance of the HPV infection through both the p16 expression status and the oncogenic HPV DNA viral load. Methods A retrospective chart review was conducted on all patients treated for oropharyngeal SCC between January 2007 and June 2009. P16 expression status by immunohistochemistry and HPV DNA viral load by quantitative polymerase chain reaction (qPCR) were evaluated on routine pretreatment tumor samples. Results One hundred thirty-three patients (94 men and 39 women) were included in the study. Mean age was 59 years. One hundred twenty-two lesions (92%) were localized to lymphoid areas. Sixty-seven patients (50%) were p16+, and 87 patients (65%) harbored HPV DNA. The p16+/HPV DNA+ profile (48%) was associated with the most favorable prognosis. HPV16 was responsible for the majority of the infections (89%). Conclusion HPV is common among oropharyngeal SCC in France, and acts as an independent prognostic factor.

KW - human papillomavirus

KW - oropharynx

KW - p16

KW - quantitative polymerase chain reaction

KW - squamous cell carcinoma

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