Hyperandrogenism in a postmenopausal woman presenting with a metastatic ileum endocrine tumor

Anne Bachelot, Geri Meduri, Eric Baudin, Frédérique Kuttenn, Philippe Touraine

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    8 Citations (Scopus)

    Résumé

    Objective To elucidate the mechanism of the hyperandrogenism found in a postmenopausal woman presenting an ileum endocrine tumor with ovarian metastases. Design Case report. Setting University hospital. Patient(s) A postmenopausal woman was referred for hirsutism. Basal plasma testosterone was high, 6.6 nM/L (normal, ≤0.7 nM/L). Pelvic magnetic resonance imaging revealed a 6-cm left ovarian mass. Intervention(s) Bilateral salpingo-oophorectomy was performed. Pathological examination found a bilateral metastatic endocrine ovarian tumor, associated with a functional stroma. A primary ileum endocrine tumor was discovered and resected. Main outcome measure(s) Immunohistochemical study of the expression of steroidogenic enzymes and β and α subunits of hCG. Result(s) Immunohistochemical expression of steroidogenic enzymes was found in the ovarian stromal tissue surrounding the tumor but not in the metastatic tumoral cells. A substantial percentage of the metastatic tumoral cells was immunopositive for the β and α subunit of hCG but not the ileal cells. Conclusion(s) These data suggest an hCG paracrine effect of the ovarian metastases tumor on the adjacent interstitial cells, resulting in the virilization of the patient.

    langue originaleAnglais
    Pages (de - à)675-678
    Nombre de pages4
    journalFertility and Sterility
    Volume81
    Numéro de publication3
    Les DOIs
    étatPublié - 1 mars 2004

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