Résumé
Objective To elucidate the mechanism of the hyperandrogenism found in a postmenopausal woman presenting an ileum endocrine tumor with ovarian metastases. Design Case report. Setting University hospital. Patient(s) A postmenopausal woman was referred for hirsutism. Basal plasma testosterone was high, 6.6 nM/L (normal, ≤0.7 nM/L). Pelvic magnetic resonance imaging revealed a 6-cm left ovarian mass. Intervention(s) Bilateral salpingo-oophorectomy was performed. Pathological examination found a bilateral metastatic endocrine ovarian tumor, associated with a functional stroma. A primary ileum endocrine tumor was discovered and resected. Main outcome measure(s) Immunohistochemical study of the expression of steroidogenic enzymes and β and α subunits of hCG. Result(s) Immunohistochemical expression of steroidogenic enzymes was found in the ovarian stromal tissue surrounding the tumor but not in the metastatic tumoral cells. A substantial percentage of the metastatic tumoral cells was immunopositive for the β and α subunit of hCG but not the ileal cells. Conclusion(s) These data suggest an hCG paracrine effect of the ovarian metastases tumor on the adjacent interstitial cells, resulting in the virilization of the patient.
langue originale | Anglais |
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Pages (de - à) | 675-678 |
Nombre de pages | 4 |
journal | Fertility and Sterility |
Volume | 81 |
Numéro de publication | 3 |
Les DOIs | |
état | Publié - 1 mars 2004 |