TY - JOUR
T1 - Hypoglycemic Activity of Aqueous Extract of Eucalyptus globulus in Normal and Streptozotocin-Induced Diabetic Rats
AU - Jouad, Hassan
AU - Maghrani, Mhamed
AU - El Hassani, Rabii Ameziane
AU - Eddouks, Mohamed
PY - 2003/12/1
Y1 - 2003/12/1
N2 - Single and repeated oral administration of the aqueous extract of Eucalyptus globulus leaves at the doses of 150 and 300 mg/kg body weight exhibited a significant, dose-dependent hypoglycemic effect in streptozotocin diabetic rats. In rats with a normal functioning pancreas, however, no significant changes in blood glucose levels were observed after a single or repeated oral administration of Eucalyptus globulus leaf extract. In diabetic rats, the repeated oral administration of Eucalyptus globulus aqueous leaf extract significantly increased the basal plasma insulin concentrations (P < 0.05). The oral acute toxicity study in mice demonstrated that the LD 50 value for the Eucalyptus globulus leaf tissue was 4.5 g/kg. The results support the validity of empirical uses of EG in the treatment of diabetes mellitus.
AB - Single and repeated oral administration of the aqueous extract of Eucalyptus globulus leaves at the doses of 150 and 300 mg/kg body weight exhibited a significant, dose-dependent hypoglycemic effect in streptozotocin diabetic rats. In rats with a normal functioning pancreas, however, no significant changes in blood glucose levels were observed after a single or repeated oral administration of Eucalyptus globulus leaf extract. In diabetic rats, the repeated oral administration of Eucalyptus globulus aqueous leaf extract significantly increased the basal plasma insulin concentrations (P < 0.05). The oral acute toxicity study in mice demonstrated that the LD 50 value for the Eucalyptus globulus leaf tissue was 4.5 g/kg. The results support the validity of empirical uses of EG in the treatment of diabetes mellitus.
KW - Diabetes
KW - Medicinal plant
KW - Pharmacological effect
KW - Traditional medicine
UR - http://www.scopus.com/inward/record.url?scp=1942520953&partnerID=8YFLogxK
U2 - 10.1300/J044v10n04_03
DO - 10.1300/J044v10n04_03
M3 - Article
AN - SCOPUS:1942520953
SN - 1049-6475
VL - 10
SP - 19
EP - 28
JO - Journal of Herbs, Spices and Medicinal Plants
JF - Journal of Herbs, Spices and Medicinal Plants
IS - 4
ER -