Hypoglycemic Activity of Aqueous Extract of Eucalyptus globulus in Normal and Streptozotocin-Induced Diabetic Rats

Hassan Jouad, Mhamed Maghrani, Rabii Ameziane El Hassani, Mohamed Eddouks

Résultats de recherche: Contribution à un journalArticleRevue par des pairs

21 Citations (Scopus)

Résumé

Single and repeated oral administration of the aqueous extract of Eucalyptus globulus leaves at the doses of 150 and 300 mg/kg body weight exhibited a significant, dose-dependent hypoglycemic effect in streptozotocin diabetic rats. In rats with a normal functioning pancreas, however, no significant changes in blood glucose levels were observed after a single or repeated oral administration of Eucalyptus globulus leaf extract. In diabetic rats, the repeated oral administration of Eucalyptus globulus aqueous leaf extract significantly increased the basal plasma insulin concentrations (P < 0.05). The oral acute toxicity study in mice demonstrated that the LD 50 value for the Eucalyptus globulus leaf tissue was 4.5 g/kg. The results support the validity of empirical uses of EG in the treatment of diabetes mellitus.

langue originaleAnglais
Pages (de - à)19-28
Nombre de pages10
journalJournal of Herbs, Spices and Medicinal Plants
Volume10
Numéro de publication4
Les DOIs
étatPublié - 1 déc. 2003
Modification externeOui

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