Identification et prise en charge d’un haut risque de cancer du sein. État des lieux 2014

Breast cancer is the most common cancer diagnosed and the first leading cause of cancer death among women in France. A population of women at high risk of breast cancer (more than 3% risk at 5 years and 20–25% lifetime) can nowadays be identified and benefit from an appropriate personalized prevention and monitoring program. The French national health authority (HAS, Haute Autorité de Santé) considers personal germline mutation of BRCA1/2, TP53, PTEN, CDH1 or STK11/LKB1 genes, but also recently personal breast cancer history, personal history of atypical breast lesion, history of high-dose chest irradiation and striking family breast/ovarian cancer history but without identified mutation, as criteria of high breast cancer risk and provides screening recommendations for these women.