Identification of DNA ligase I related polypeptides in three different human cells

C. Prigent, S. Aoufouchi, M. Philippe

Résultats de recherche: Contribution à un journalArticleRevue par des pairs

4 Citations (Scopus)

Résumé

Partial purification of the DNA ligase from three human tissues (liver, thymus and lymphoblasts) revealed that each cell type contains several different polypeptides bearing a DNA ligase I activity. Their apparent molecular weights estimated after SDS PAGE, 130 kDa, 100 kDa and 80 kDa, are in agreement with previous reports. These polypeptides are related by proteolysis to a single higher molecular weight protein of 200 kDa which does not show DNA ligase activity but that could be a preprotein.

langue originaleAnglais
Pages (de - à)888-895
Nombre de pages8
journalBiochemical and Biophysical Research Communications
Volume169
Numéro de publication3
Les DOIs
étatPublié - 29 juin 1990
Modification externeOui

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