Résumé
What is a stem cell? Is stemness an intrinsic or extrinsic property? What role does the microenvironment play in the stemness identity? We distinguish four identities for normal and cancerous stem cells and explore their consequences for therapeutic strategy choice in the oncology setting. Acquisition of genetic and epigenetic alterations during cell transformation and disease progression questions the stability of the stemness property's identity in cancers.
| Titre traduit de la contribution | The identity of normal and cancer stem cells |
|---|---|
| langue originale | Français |
| Pages (de - à) | 899-904 |
| Nombre de pages | 6 |
| journal | Medecine/Sciences |
| Volume | 33 |
| Numéro de publication | 10 |
| Les DOIs | |
| état | Publié - 1 janv. 2017 |