Résumé
IDH mutants cause aberrant DNA and histone methylation and contribute to hematological and neuronal malignancies. In this issue of Cancer Cell, Inoue et al. describe a potential specific effect of IDH1 mutations that reduces Atm expression via inhibition of H3K9 demethylases, which may represent a first step toward cellular transformation.
langue originale | Anglais |
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Pages (de - à) | 192-194 |
Nombre de pages | 3 |
journal | Cancer Cell |
Volume | 30 |
Numéro de publication | 2 |
Les DOIs | |
état | Publié - 8 août 2016 |