Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients

Marion Picard; Satoru Yonekura; Karolina Slowicka; Ioanna Petta; Conrad Rauber; Bertrand Routy; Corentin Richard; Valerio Iebba; Maryam Tidjani Alou; Sonia Becharef; Pierre Ly; Eugenie Pizzato; Christian H.K. Lehmann; Lukas Amon; Christophe Klein; Paule Opolon; Ivo Gomperts Boneca; Jean Yves Scoazec; Antoine Hollebecque; David Malka; François Ghiringhelli; Diana Dudziak; Geert Berx; Lars Vereecke; Geert van Loo; Guido Kroemer; Laurence Zitvogel; Maria Paula Roberti

doi:10.1038/s41418-020-00684-w

Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients

Marion Picard, Satoru Yonekura, Karolina Slowicka, Ioanna Petta, Conrad Rauber, Bertrand Routy, Corentin Richard, Valerio Iebba, Maryam Tidjani Alou, Sonia Becharef, Pierre Ly, Eugenie Pizzato, Christian H.K. Lehmann, Lukas Amon, Christophe Klein, Paule Opolon, Ivo Gomperts Boneca, Jean Yves Scoazec, Antoine Hollebecque, David MalkaFrançois Ghiringhelli, Diana Dudziak, Geert Berx, Lars Vereecke, Geert van Loo, Guido Kroemer, Laurence Zitvogel, Maria Paula Roberti

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

14 Citations (Scopus)

Résumé

Ileal epithelial cell apoptosis and the local microbiota modulate the effects of oxaliplatin against proximal colon cancer by modulating tumor immunosurveillance. Here, we identified an ileal immune profile associated with the prognosis of colon cancer and responses to chemotherapy. The whole immune ileal transcriptome was upregulated in poor-prognosis patients with proximal colon cancer, while the colonic immunity of healthy and neoplastic areas was downregulated (except for the Th17 fingerprint) in such patients. Similar observations were made across experimental models of implanted and spontaneous murine colon cancer, showing a relationship between carcinogenesis and ileal inflammation. Conversely, oxaliplatin-based chemotherapy could restore a favorable, attenuated ileal immune fingerprint in responders. These results suggest that chemotherapy inversely shapes the immune profile of the ileum–tumor axis, influencing clinical outcome.

langue originale	Anglais
Pages (de - à)	1532-1547
Nombre de pages	16
journal	Cell Death and Differentiation
Volume	28
Numéro de publication	5
Les DOIs	https://doi.org/10.1038/s41418-020-00684-w
état	Publié - 1 mai 2021

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10.1038/s41418-020-00684-w

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Picard, M., Yonekura, S., Slowicka, K., Petta, I., Rauber, C., Routy, B., Richard, C., Iebba, V., Tidjani Alou, M., Becharef, S., Ly, P., Pizzato, E., Lehmann, C. H. K., Amon, L., Klein, C., Opolon, P., Gomperts Boneca, I., Scoazec, J. Y., Hollebecque, A., ... Roberti, M. P. (2021). Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients. Cell Death and Differentiation, 28(5), 1532-1547. https://doi.org/10.1038/s41418-020-00684-w

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title = "Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients",

abstract = "Ileal epithelial cell apoptosis and the local microbiota modulate the effects of oxaliplatin against proximal colon cancer by modulating tumor immunosurveillance. Here, we identified an ileal immune profile associated with the prognosis of colon cancer and responses to chemotherapy. The whole immune ileal transcriptome was upregulated in poor-prognosis patients with proximal colon cancer, while the colonic immunity of healthy and neoplastic areas was downregulated (except for the Th17 fingerprint) in such patients. Similar observations were made across experimental models of implanted and spontaneous murine colon cancer, showing a relationship between carcinogenesis and ileal inflammation. Conversely, oxaliplatin-based chemotherapy could restore a favorable, attenuated ileal immune fingerprint in responders. These results suggest that chemotherapy inversely shapes the immune profile of the ileum–tumor axis, influencing clinical outcome.",

author = "Marion Picard and Satoru Yonekura and Karolina Slowicka and Ioanna Petta and Conrad Rauber and Bertrand Routy and Corentin Richard and Valerio Iebba and {Tidjani Alou}, Maryam and Sonia Becharef and Pierre Ly and Eugenie Pizzato and Lehmann, {Christian H.K.} and Lukas Amon and Christophe Klein and Paule Opolon and {Gomperts Boneca}, Ivo and Scoazec, {Jean Yves} and Antoine Hollebecque and David Malka and Fran{\c c}ois Ghiringhelli and Diana Dudziak and Geert Berx and Lars Vereecke and {van Loo}, Geert and Guido Kroemer and Laurence Zitvogel and Roberti, {Maria Paula}",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2021",

month = may,

day = "1",

doi = "10.1038/s41418-020-00684-w",

language = "English",

volume = "28",

pages = "1532--1547",

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Picard, M, Yonekura, S, Slowicka, K, Petta, I, Rauber, C, Routy, B, Richard, C, Iebba, V, Tidjani Alou, M, Becharef, S, Ly, P, Pizzato, E, Lehmann, CHK, Amon, L, Klein, C, Opolon, P, Gomperts Boneca, I, Scoazec, JY, Hollebecque, A, Malka, D, Ghiringhelli, F, Dudziak, D, Berx, G, Vereecke, L, van Loo, G, Kroemer, G, Zitvogel, L & Roberti, MP 2021, 'Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients', Cell Death and Differentiation, VOL. 28, Numéro 5, p. 1532-1547. https://doi.org/10.1038/s41418-020-00684-w

TY - JOUR

T1 - Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients

AU - Picard, Marion

AU - Yonekura, Satoru

AU - Slowicka, Karolina

AU - Petta, Ioanna

AU - Rauber, Conrad

AU - Routy, Bertrand

AU - Richard, Corentin

AU - Iebba, Valerio

AU - Tidjani Alou, Maryam

AU - Becharef, Sonia

AU - Ly, Pierre

AU - Pizzato, Eugenie

AU - Lehmann, Christian H.K.

AU - Amon, Lukas

AU - Klein, Christophe

AU - Opolon, Paule

AU - Gomperts Boneca, Ivo

AU - Scoazec, Jean Yves

AU - Hollebecque, Antoine

AU - Malka, David

AU - Ghiringhelli, François

AU - Dudziak, Diana

AU - Berx, Geert

AU - Vereecke, Lars

AU - van Loo, Geert

AU - Kroemer, Guido

AU - Zitvogel, Laurence

AU - Roberti, Maria Paula

PY - 2021/5/1

Y1 - 2021/5/1

N2 - Ileal epithelial cell apoptosis and the local microbiota modulate the effects of oxaliplatin against proximal colon cancer by modulating tumor immunosurveillance. Here, we identified an ileal immune profile associated with the prognosis of colon cancer and responses to chemotherapy. The whole immune ileal transcriptome was upregulated in poor-prognosis patients with proximal colon cancer, while the colonic immunity of healthy and neoplastic areas was downregulated (except for the Th17 fingerprint) in such patients. Similar observations were made across experimental models of implanted and spontaneous murine colon cancer, showing a relationship between carcinogenesis and ileal inflammation. Conversely, oxaliplatin-based chemotherapy could restore a favorable, attenuated ileal immune fingerprint in responders. These results suggest that chemotherapy inversely shapes the immune profile of the ileum–tumor axis, influencing clinical outcome.

AB - Ileal epithelial cell apoptosis and the local microbiota modulate the effects of oxaliplatin against proximal colon cancer by modulating tumor immunosurveillance. Here, we identified an ileal immune profile associated with the prognosis of colon cancer and responses to chemotherapy. The whole immune ileal transcriptome was upregulated in poor-prognosis patients with proximal colon cancer, while the colonic immunity of healthy and neoplastic areas was downregulated (except for the Th17 fingerprint) in such patients. Similar observations were made across experimental models of implanted and spontaneous murine colon cancer, showing a relationship between carcinogenesis and ileal inflammation. Conversely, oxaliplatin-based chemotherapy could restore a favorable, attenuated ileal immune fingerprint in responders. These results suggest that chemotherapy inversely shapes the immune profile of the ileum–tumor axis, influencing clinical outcome.

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U2 - 10.1038/s41418-020-00684-w

DO - 10.1038/s41418-020-00684-w

M3 - Article

C2 - 33262469

AN - SCOPUS:85096970461

SN - 1350-9047

VL - 28

SP - 1532

EP - 1547

JO - Cell Death and Differentiation

JF - Cell Death and Differentiation

IS - 5

ER -