Image-guided ablation of malignant liver tumors: Recommendations for clinical validation of novel thermal and non-thermal technologies - A western perspective

Riccardo Lencioni, Thierry De Baere, Robert C. Martin, Charles W. Nutting, Govindarajan Narayanan

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    92 Citations (Scopus)

    Résumé

    Background: Image-guided ablation is used to treat patients with unresectable malignant hepatic tumors that are limited in number and size, especially hepatocellular carcinoma (HCC) and colorectal hepatic metastases. While radiofrequency ablation (RFA) has been the most popular technique, several alternate options for focal tissue destruction have recently attracted attention. These technologies appear to be able to overcome some specific limitations of RFA. Currently, there is no accepted algorithm for the use of the different techniques for image-guided ablation. Summary: A panel of physicians practicing in North America or Europe met to develop a set of recommendations aimed at providing directions for clinical validation of energy-based, thermal and non-thermal image-guided ablation technologies in the treatment of malignant liver tumors. The recommendations were developed through a critical appraisal of potential advantages and disadvantages of each ablation technology, based on experimental findings and available data, as well as on critical considerations for their clinical validation in hepatic tumor treatment from a Western perspective. Key Messages: Significant variability appears to exist among the different equipment and devices within each type of technology. A comprehensive understanding of the data and a critical appraisal of the efficacy and safety profile of each ablation system is required. Clinical practice guidelines should include specific information of the recommended techniques and protocols instead of a generic indication of the technology.

    langue originaleAnglais
    Pages (de - à)208-214
    Nombre de pages7
    journalLiver Cancer
    Volume4
    Numéro de publication4
    Les DOIs
    étatPublié - 1 déc. 2015

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