TY - JOUR
T1 - Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups
AU - Lobón-Iglesias, María Jesús
AU - Andrianteranagna, Mamy
AU - Han, Zhi Yan
AU - Chauvin, Céline
AU - Masliah-Planchon, Julien
AU - Manriquez, Valeria
AU - Tauziede-Espariat, Arnault
AU - Turczynski, Sandrina
AU - Bouarich-Bourimi, Rachida
AU - Frah, Magali
AU - Dufour, Christelle
AU - Blauwblomme, Thomas
AU - Cardoen, Liesbeth
AU - Pierron, Gaelle
AU - Maillot, Laetitia
AU - Guillemot, Delphine
AU - Reynaud, Stéphanie
AU - Bourneix, Christine
AU - Pouponnot, Célio
AU - Surdez, Didier
AU - Bohec, Mylene
AU - Baulande, Sylvain
AU - Delattre, Olivier
AU - Piaggio, Eliane
AU - Ayrault, Olivier
AU - Waterfall, Joshua J.
AU - Servant, Nicolas
AU - Beccaria, Kevin
AU - Dangouloff-Ros, Volodia
AU - Bourdeaut, Franck
N1 - Publisher Copyright:
© 2023, Springer Nature Limited.
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Atypical teratoid rhabdoid tumors (ATRT) are divided into MYC, TYR and SHH subgroups, suggesting diverse lineages of origin. Here, we investigate the imaging of human ATRT at diagnosis and the precise anatomic origin of brain tumors in the Rosa26-CreERT2::Smarcb1flox/flox model. This cross-species analysis points to an extra-cerebral origin for MYC tumors. Additionally, we clearly distinguish SHH ATRT emerging from the cerebellar anterior lobe (CAL) from those emerging from the basal ganglia (BG) and intra-ventricular (IV) regions. Molecular characteristics point to the midbrain-hindbrain boundary as the origin of CAL SHH ATRT, and to the ganglionic eminence as the origin of BG/IV SHH ATRT. Single-cell RNA sequencing on SHH ATRT supports these hypotheses. Trajectory analyses suggest that SMARCB1 loss induces a de-differentiation process mediated by repressors of the neuronal program such as REST, ID and the NOTCH pathway.
AB - Atypical teratoid rhabdoid tumors (ATRT) are divided into MYC, TYR and SHH subgroups, suggesting diverse lineages of origin. Here, we investigate the imaging of human ATRT at diagnosis and the precise anatomic origin of brain tumors in the Rosa26-CreERT2::Smarcb1flox/flox model. This cross-species analysis points to an extra-cerebral origin for MYC tumors. Additionally, we clearly distinguish SHH ATRT emerging from the cerebellar anterior lobe (CAL) from those emerging from the basal ganglia (BG) and intra-ventricular (IV) regions. Molecular characteristics point to the midbrain-hindbrain boundary as the origin of CAL SHH ATRT, and to the ganglionic eminence as the origin of BG/IV SHH ATRT. Single-cell RNA sequencing on SHH ATRT supports these hypotheses. Trajectory analyses suggest that SMARCB1 loss induces a de-differentiation process mediated by repressors of the neuronal program such as REST, ID and the NOTCH pathway.
UR - http://www.scopus.com/inward/record.url?scp=85174547491&partnerID=8YFLogxK
U2 - 10.1038/s41467-023-42371-7
DO - 10.1038/s41467-023-42371-7
M3 - Article
AN - SCOPUS:85174547491
SN - 2041-1723
VL - 14
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 6669
ER -