TY - JOUR
T1 - Immunogenetic analysis of spontaneous autoimmune thyroiditis of obese strain chickens
AU - Kroemer, Guido
AU - Neu, Nikolaus
AU - Kuehr, Thomas
AU - Dietrich, Hermann
AU - Fässler, Reinhard
AU - Hala, Karel
AU - Wick, G.
N1 - Funding Information:
This work was supported by the Austrian Research Council (Grant S41/05), by the Jubilaeumsfonds of the Austrian National Bank (project No. 2784) and by the Kamillo-Eisner Foundation, Hergiswil, Switzerland. The authors thank Ms. Regine Gerth, Ms. Ingrid Zoderer, and Mrs. Pia Mueller for excellent technical assistance. The helpful comments of Dr. Karine Trail1 are gratefully acknowledged.
PY - 1989/1/1
Y1 - 1989/1/1
N2 - A variety of immunological, endocrinological, and virological abnormalities have been implicated in the etiopathogenesis of spontaneous autoimmune thyroiditis (SAT) of Obese strain (OS) chickens, e.g., a general T cell hyperreactivity, an increased uptake of iodine into the thyroid gland, a diminution of the glucocorticoid tonus, and an OS-specific endogenous virus. In crosses of the close-bred OS B15 B15 subline with the inbred normal CB B12 B12 strain we have studied the mode of inheritance of these aberrations and their putative association with SAT. The results indicate that none of these OS-specific characteristics alone is an absolute prerequisite for the development of thyroid infiltration, which appears to be governed by one autosomal recessive gene.
AB - A variety of immunological, endocrinological, and virological abnormalities have been implicated in the etiopathogenesis of spontaneous autoimmune thyroiditis (SAT) of Obese strain (OS) chickens, e.g., a general T cell hyperreactivity, an increased uptake of iodine into the thyroid gland, a diminution of the glucocorticoid tonus, and an OS-specific endogenous virus. In crosses of the close-bred OS B15 B15 subline with the inbred normal CB B12 B12 strain we have studied the mode of inheritance of these aberrations and their putative association with SAT. The results indicate that none of these OS-specific characteristics alone is an absolute prerequisite for the development of thyroid infiltration, which appears to be governed by one autosomal recessive gene.
UR - http://www.scopus.com/inward/record.url?scp=0024344751&partnerID=8YFLogxK
U2 - 10.1016/0090-1229(89)90172-4
DO - 10.1016/0090-1229(89)90172-4
M3 - Article
C2 - 2786782
AN - SCOPUS:0024344751
SN - 0090-1229
VL - 52
SP - 202
EP - 213
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 2
ER -