TY - JOUR
T1 - Immunogenic cell death in cancer
T2 - concept and therapeutic implications
AU - Galluzzi, Lorenzo
AU - Kepp, Oliver
AU - Hett, Erik
AU - Kroemer, Guido
AU - Marincola, Francesco M.
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Mammalian cells responding to specific perturbations of homeostasis can undergo a regulated variant of cell death that elicits adaptive immune responses. As immunogenic cell death (ICD) can only occur in a precise cellular and organismal context, it should be conceptually differentiated from instances of immunostimulation or inflammatory responses that do not mechanistically depend on cellular demise. Here, we critically discuss key conceptual and mechanistic aspects of ICD and its implications for cancer (immuno)therapy.
AB - Mammalian cells responding to specific perturbations of homeostasis can undergo a regulated variant of cell death that elicits adaptive immune responses. As immunogenic cell death (ICD) can only occur in a precise cellular and organismal context, it should be conceptually differentiated from instances of immunostimulation or inflammatory responses that do not mechanistically depend on cellular demise. Here, we critically discuss key conceptual and mechanistic aspects of ICD and its implications for cancer (immuno)therapy.
KW - Antigenicity
KW - CAR T cells
KW - DAMPs
KW - Immune checkpoint inhibitors
KW - Pattern recognition receptors
KW - Tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85149318534&partnerID=8YFLogxK
U2 - 10.1186/s12967-023-04017-6
DO - 10.1186/s12967-023-04017-6
M3 - Review article
C2 - 36864446
AN - SCOPUS:85149318534
SN - 1479-5876
VL - 21
JO - Journal of Translational Medicine
JF - Journal of Translational Medicine
IS - 1
M1 - 162
ER -